B Cell Markers
View the Stages of B Cell Development and Cell Type-Specific Markers |
The production of mature B cells occurs through a series of processes that take place in the bone marrow, spleen, and other peripheral lymphoid organs. Clusters of Differentiation (CD) proteins are a group of cell surface markers that can be used to identify different stages of B cell development or activation, including progenitor B cells, pre-pro-B cells, pro-B cells, pre-B cells, immature B cells, transitional B cells, marginal zone B cells, follicular B cells, activated germinal center B cells, memory B cells, plasmablasts, and plasma cells. Other positive and negative markers used to identify specific stages of B cell development or activation are also listed.
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Progenitor B Cell
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Mouse B1 or B2 Progenitor Cell
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Pre-Pro B Cell
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Human Transitional B Cell
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Mouse Transitional 1 (T1) or Transitional 2 (T2) B Cell (from B2 Progenitor Cell)
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Mouse B1a or B1b Cell (from B1 Progenitor Cell)
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Marginal Zone B Cell
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Activated Germinal Center B Cell
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Plasmablast
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Regulatory B Cell
- B220/CD45R
- B7-1/CD80
- B7-2/CD86
- BLIMP1/PRDM1
- CD1d
- CD5
- CD11b/Integrin alpha M
- CD19
- CD21
- CD23/Fc epsilon RII
- CD24
- CD27/TNFRSF7
- CD38
- CD40/TNFRSF5
- CD44
- CD69
- CD72
- CD20
- CD25/IL-2R alpha
- CXCR4
- DEP-1/CD148
- EBI3
- EMMPRIN/CD147
- HLA-DR
- IgM
- IL-10
- IL-12 R beta 2
- IL-12/IL-35 p35
- IL-21
- IL-21R
- IL-23/IL-39 p19
- IL-27 R alpha/WSX-1/TCCR
- IL-39 (IL-23p19/EBI3)
- IRF4
- Siglec-2/CD22
- STAT1
- STAT3
- Syndecan-1/CD138
- TACI/TNFRSF13B
- TGF-beta
- TIM-1/KIM-1/HAVCR
- TLR4