Recombinant Active Protein Kinases

Protein kinases play critical roles in signal transduction, and their physiological activities in cellular processes are important in defining signaling pathways. Likewise, unregulated activities of protein kinases are of particular interest in understanding pathological pro­cesses such as cancer and chronic inflam­matory diseases. Protein kinases often have multiple physiological substrates and cellular functions. Therefore, specific inhibitors of pro­tein kinases are of interest in drug de­velopment. R&D Systems now offers a wide range of new recombinant active kinases that can be used in studies of their activities and inhibitors. These include members of the Src family, and kinases involved in the PI 3-kinase and MAP kinase signaling pathways.