DMPQ dihydrochloride
Chemical Name: 5,7-Dimethoxy-3-(4-pyridinyl)quinoline dihydrochloride
Purity: ≥99%
Biological Activity
DMPQ dihydrochloride is a potent and selective inhibitor of human vascular β-type platelet derived growth factor receptor tyrosine kinase (PDGFRβ) (IC50 = 80 nM). Displays > 100-fold selectivity over EGFR tyrosine kinase, erbB2, p56, protein kinase A and protein kinase C.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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5,7-Dimethoxy-3-(4-pyridinyl)quinoline is a potent and selective inhibitor of human vascular β-type platelet-derived growth factor receptor tyrosine kinase
Dolle et al.
J.Med.Chem., 1994;37:2627
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Citation for DMPQ dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for DMPQ dihydrochloride include:
1 Citation: Showing 1 - 1
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Substrate stiffness modulates the multipotency of human neural crest derived ectomesenchymalstem cells via CD44 mediated PDGFR signaling.
Authors: Srinivasan
Biomaterials 2018;167:153
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