Human CCL8/MCP-2 Biotinylated Antibody Summary
Gln24-Pro99
Accession # P80075
Applications
Human CCL8/MCP-2 Sandwich Immunoassay
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: CCL8/MCP-2
MCP-2 and MCP-3 are two monocyte chemotactic proteins produced by human MG-63 osteosarcoma cells. Both MCP-2 and MCP-3 are members of the C-C family of chemokines and share 62% and 71% amino acid sequence identity, respectively, with MCP-1. MCP-3 also shares 58% amino acid identity with MCP-2.
Similar to other C-C chemokines, all three MCP proteins are monocyte chemoattractants. In addition, the three MCPs can chemoattract activated NK cells as well as CD4+ and CD8+ T lymphocytes. All three cytokines have also been shown to attract eosinophils and induce histamine secretion from basophils.
Product Datasheets
Citations for Human CCL8/MCP-2 Biotinylated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 4
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A Toll-like receptor-1 variant and its characteristic cellular phenotype is associated with severe malaria in Papua New Guinean children.
Authors: Manning L, Cutts J, Stanisic D, Laman M, Carmagnac A, Allen S, O'Donnell A, Karunajeewa H, Rosanas-Urgell A, Siba P, Davis T, Michon P, Schofield L, Rockett K, Kwiatkowski D, Mueller I
Genes Immun, 2015-12-03;17(1):52-9.
Species: Human
Sample Types: Cell Culture Supernates
Applications: ELISA Development (Detection) -
Allergen challenge in vivo alters rhinovirus-induced chemokine secretion from human airway macrophages.
Authors: Karta, Maya R, Wickert, Lisa E, Curran, Colleen, Gavala, Monica L, Denlinger, Loren C, Gern, James E, Bertics, Paul J
J Allergy Clin Immunol, 2014-02-14;133(4):1227-30.
Species: Human
Sample Types: Whole Cells
Applications: ELISA Development (Detection) -
Synergistic up-regulation of MCP-2/CCL8 activity is counteracted by chemokine cleavage, limiting its inflammatory and anti-tumoral effects.
Authors: Struyf S, Proost P, Vandercappellen J
Eur. J. Immunol., 2009-03-01;39(3):843-57.
Species: Human
Sample Types: Cell Culture Supernates
Applications: ELISA Development -
Effect of cognate human CD4+ T cell and endothelial cell interactions upon chemokine production.
Authors: Tay SS, McCormack A, Rose ML
Transplantation, 2004-10-15;78(7):987-94.
Species: Human
Sample Types: Cell Culture Supernates
Applications: ELISA Development
FAQs
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Good detection in disease samples
This antibody was used with MAB281 to build an ELISA to measure MCP-2 in human serum samples.
