Human/Primate TRAIL/TNFSF10 Biotinylated Antibody Summary
Thr95-Gly281
Accession # P50591
Applications
Human/Primate TRAIL/TNFSF10 Sandwich Immunoassay
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: TRAIL/TNFSF10
TRAIL (TNF-related apoptosis-inducing ligand), also known as APO-2 ligand, is a type II transmembrane protein with a carboxy-terminal extracellular domain which exhibits homology to other TNF family members. In the new TNF superfamily nomenclature, TRAIL is referred to as TNFSF10. Human TRAIL cDNA encodes a 281 amino acid (aa) residue protein with an amino-terminal intracellular domain of 17 residues and a predicted internal hydrophobic domain between residues 18 and 38. The extracellular carboxy-terminal domain contains a potential N-linked glycosylation site at amino acid residue 109. Among TNF family members, TRAIL is most homologous to FAS ligand, sharing 28% amino acid sequence identity in their extracellular domains. Mouse TRAIL has also been cloned. The human TRAIL shares 65% amino acid sequence identity with mouse TRAIL and is active on mouse cells. Both membrane bound and soluble TRAIL have been shown to induce rapid apoptosis of many transformed cell lines. Like most TNF family members, the bioactive TRAIL exists as a homotrimer. TRAIL transcripts have been shown to be constitutively expressed in a variety of human tissues. A family of TRAIL receptors, including two receptors that tranduce the apoptotic signals and two TRAIL decoy receptors that function to antagonize TRAIL-induced apoptosis, have been identified (1-3). Osteoprotegerin has been identified as a fifth TRAIL receptor (4).
- Golstein, P. (1997) Current Biology 7:R750.
- Wiley, S.R. et al. (1995) Immunity 3:673.
- Pitti, R.M. et al. (1996) J. Biol. Chem. 271:12687.
- Emery, J. et al. (1998) J. Biol. Chem. 273:14363.
Product Datasheets
Citations for Human/Primate TRAIL/TNFSF10 Biotinylated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Mammalian target of rapamycin contributes to the acquired apoptotic resistance of human mesothelioma multicellular spheroids.
Authors: Barbone D, Yang TM, Morgan JR
J. Biol. Chem., 2008-03-13;283(19):13021-30.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-P -
Measle virus-infected dendritic cells develop immunosuppressive and cytotoxic activities.
Authors: Vidalain PO, Azocar O, Rabourdin-Combe C, Servet-Delprat C
Immunobiology, 2001-12-01;204(5):629-38.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry
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