Home / Nicotinic (a7) Receptor Modulators / Ivermectin

Ivermectin

Catalog #: 1260
5 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
1260/100
Ivermectin | CAS No. 70288-86-7 | Nicotinic (a7) Receptor Modulators
1 Image
Description: Positive allosteric modulator of α7 nAChRs; also positive allosteric modulator of P2X4 receptors

Chemical Name: 22,23-Dihydroavermectin B1

Purity: ≥96%

Product Details
Citations (5)
Supplemental Products
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

Ivermectin is a positive allosteric modulator of the α7 neuronal nicotinic acetylcholine receptor and the purinergic P2X4 receptor. Antihelmintic and antiviral. Also modulates glutamate- and GABA-activated chloride channels. Potentiates glycine-gated currents at low concentrations (30 nM). Inhibits replication of SARS-CoV-2 in vitro (IC50 ~ 2μM).

This product is composed of both Ivermectin B1a (>90%) and Ivermectin B1b.

Technical Data

M.Wt:
875.1
Formula:
C48H74O14 (B1a form)
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥96%
Storage:
Desiccate at +4°C
CAS No:
70288-86-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for Ivermectin

The citations listed below are publications that use Tocris products. Selected citations for Ivermectin include:

5 Citations: Showing 1 - 5

  1. Ginsenosides Act As Positive Modulators of P2X4 Receptors.
    Authors: Dhuna Et al.
    Mol Pharmacol  2019;95:210
  2. A biofidelic 3D culture model to study the development of brain cellular systems.
    Authors: Ren Et al.
    Pharmacol Res Perspect  2016;6:24953
  3. Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells.
    Authors: Dolma Et al.
    Cancer Cell  2016;29:859
  4. Natural compounds with P2X7 receptor-modulating properties.
    Authors: Fischer Et al.
    Purinergic Signal  2013;10:313
  5. Positive allosteric modulation by iverm. of human but not murine P2X7 receptors.
    Authors: Nörenberg Et al.
    Br J Pharmacol  2012;167:48

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for Ivermectin

There are currently no reviews for this product. Be the first to review Ivermectin and earn rewards!

Have you used Ivermectin?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.