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IWP 12

Catalog #: 5279 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5279/50
5279/10
IWP 12 | CAS No. 688353-45-9 | PORCN Inhibitors
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Description: Potent PORCN inhibitor; active in vivo

Chemical Name: N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-3,6-dimethyl-4-oxothieno[3,2-d]pyrimidin-2-yl)thio]acetamide

Purity: ≥98%

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Biological Activity

IWP 12 is a potent inhibitor of Porcupine (PORCN), a membrane-bound O-acyltransferase (MBOAT) (IC50 = 15 nM). Inhibits Wnt/β-catenin and Wnt/planar cell polarity (PCP) signaling pathways. Blocks zebrafish tailfin regeneration in vivo.

Technical Data

M.Wt:
418.56
Formula:
C18H18N4O2S3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
688353-45-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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