Home / GPR55 Receptor Antagonists / ML 193

ML 193

Catalog #: 4860
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4860/10
ML 193 | CAS No. 713121-80-3 | GPR55 Receptor Antagonists
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Description: Potent, selective GPR55 antagonist
Alternative Names: CID 1261822

Chemical Name: N-[4-[[(3,4-Dimethyl-5-isoxazolyl)amino]sulfonyl]phenyl]-6,8-dimethyl-2-(2-pyridinyl)-4-quinolinecarboxamide

Purity: ≥98%

Product Details
Citations (3)
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Biological Activity

ML 193 is a selective GPR55 antagonist (IC50 = 221 nM). Exhibits >27-, >145- and >145-fold selectivity for GPR55 over CB1, GPR35 and CB2, respectively. Inhibits ERK signaling in vitro.

Technical Data

M.Wt:
527.59
Formula:
C28H25N5O4S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
713121-80-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Screening for selective ligands for GPR55 - antagonists.
    Heynen-Genel et al.
    Probe Reports from the NIH Molecular Libraries Program, 2010;
  2. Identification of the GPR55 antagonist binding site using a novel set of high-potency GPR55 selective ligands.
    Kotsikorou et al.
    Biochemistry, 2013;52:9456

Product Datasheets

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Citations for ML 193

The citations listed below are publications that use Tocris products. Selected citations for ML 193 include:

3 Citations: Showing 1 - 3

  1. Role of miRNA in the regulation of cannabidiol-mediated apoptosis in neuroblastoma cells.
    Authors: Alharris Et al.
    Oncotarget  2019;10:45
  2. Anti-neuroinflammatory effects of GPR55 antagonists in LPS-activated primary microglial cells.
    Authors: Saliba Et al.
    J Neuroinflammation  2018;15:322
  3. Lysophosphatidylcholine elicits intracellular calcium signaling in GPR55-dependent manner.
    Authors: Drzazga
    Biochem Biophys Res Commun  2017;489(2):243

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