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Recombinant Human IGF-I/IGF-1 Protein, CF

Catalog #: 291-G1
213 Citations 8 Reviews Datasheet / COA / SDS
GMP Version Available: 291-GMP
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Catalog # Availability Size / Price Qty
291-G1-200
291-G1-01M
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Graph showing dose-dependent bioactivity of IGF-1 protein
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Product Details
Citations (213)
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Reviews (8)
Summary Product Datasheets Carrier Free Data Images Reconstitution Calculator Background Related Research Areas

Recombinant Human IGF-I/IGF-1 Protein, CF Summary

Product Specifications

Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin Level
<0.10 EU per 1 μg of the protein by the LAL method.
Activity
Measured in a serum-free cell proliferation assay using MCF‑7 human breast cancer cells. Karey, K.P. et al. (1988) Cancer Research 48:4083. The ED50 for this effect is 0.3-1.5 ng/mL.
Source
E. coli-derived human IGF-I/IGF-1 protein
Gly49-Ala118
Accession #
P05019
N-terminal Sequence
Analysis
Gly49
Predicted Molecular Mass
7.6 kDa
SDS-PAGE
7 kDa, reducing conditions

Product Datasheets

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291-G1

Product Datasheet
COA
SDS

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

291-G1

Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution Reconstitute at 200 μg/mL in sterile PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Scientific Data

Bioactivity Graph showing dose-dependent bioactivity of IGF-1 protein View Larger

Recombinant Human IGF-I / IGF-1 (Catalog # 291-G1) stimulates proliferation in the MCF-7 human breast cancer cell line. The ED50 for this effect is 0.3‑1.5 ng/mL.

SDS-PAGE Graph showing dose-dependent bioactivity of IGF-1 protein View Larger

1 μg/lane of Recombinant Human IGF-I / IGF-1 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 7 kDa.

Mass Spectrometry Graph showing dose-dependent bioactivity of IGF-1 protein View Larger

MALDI-TOF analysis of Recombinant Human IGF-I / IGF-1. The major peak corresponds to the calculated molecular mass, 7650 Da. The minor peak at 7873 is a matrix-associated artifact of the MALDI-TOF.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: IGF-I/IGF-1

Insulin-like growth factor I (IGF-I or IGF-1), also known as somatomedin C, is the dominant effector of growth hormone and is structurally homologous to proinsulin. Human IGF-1 is synthesized as two precursor isoforms with N- and alternate C‑terminal propeptides (1). These isoforms are differentially expressed by various tissues (1). The 7.6 kDa mature IGF-1 protein is identical between isoforms and is generated by proteolytic removal of the N- and C‑terminal regions. Mature human IGF-1 shares 94% and 96% aa sequence identity with mouse and rat IGF-1, respectively (2), and exhibits cross-species activity. It shares 64% aa sequence identity with mature human IGF-II/IGF-2. Circulating IGF-I is produced by hepatocytes, while local IGF-I is produced by many other tissues in which it has paracrine effects (1). IGF-I induces the proliferation, migration, and differentiation of a wide variety of cell types during development and postnatally (3). IGF-I regulates glucose and fatty acid metabolism, steroid hormone activity, and cartilage and bone metabolism (4‑7). It plays an important role in muscle regeneration and tumor progression (1, 8). IGF-I/IGF-1 binds IGF-I R, IGF-II R, and the insulin receptor, although its effects are mediated primarily by IGF-I R (9). The IGF-I protein associates with IGF binding proteins thereby increasing its plasma half‑life and modulating its interactions with receptors (10).

References
  1. Philippou, A. et al. (2007) In Vivo 21:45.
  2. Sandberg-Nordqvist, A.C. et al. (1992) Brain Res. Mol. Brain Res. 12:275.
  3. Guvakova, M.A. (2007) Int. J. Biochem. Cell Biol. 39:890.
  4. Clemmons, D.R. (2006) Curr. Opin. Pharmacol. 6:620.
  5. Bluher, S. et al. (2005) Best Pract. Res. Clin. Endocrinol. Metab. 19:577.
  6. Garcia-Segura, L.M. et al. (2006) Neuroendocrinology 84:275.
  7. Malemud, C.J. (2007) Clin. Chim. Acta 375:10.
  8. Samani, A.A. et al. (2007) Endocrine Rev. 28:20.
  9. LeRoith, D. and S. Yakar (2007) Nat. Clin. Pract. Endocrinol. Metab. 3:302.
  10. Denley, A. et al. (2005) Cytokine Growth Factor Rev. 16:421.
Long Name
Insulin-like Growth Factor I/Insulin-like Growth Factor 1
Entrez Gene IDs
3479 (Human); 16000 (Mouse); 24482 (Rat)
Alternate Names
IBP1; IGF1; IGF-1; IGF1A; IGFI; IGF-I; IGF-IA; IGF-IB; insulin-like growth factor 1 (somatomedin C); insulin-like growth factor 1; insulin-like growth factor I; insulin-like growth factor IA; insulin-like growth factor IB; Mechano growth factor; MGF; Somatomedin A; Somatomedin C; somatomedin-C

Citations for Recombinant Human IGF-I/IGF-1 Protein, CF

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

213 Citations: Showing 1 - 10
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  1. Enhancement of therapeutic potential of mesenchymal stem cell by IGF-1 delivery in PLGA microspheres for tissue regeneration
    Authors: Ge, M;Sun, L;Wang, D;Hei, C;Huang, T;Xu, Z;Shuai, Q;
    Regenerative therapy
    Species: olive baboon
    Sample Types: Microspheres
    Applications: Bioassay
  2. Motor neurons and endothelial cells additively promote development and fusion of human iPSC-derived skeletal myocytes
    Authors: Das, S;Hilman, MC;Yang, F;Mourkioti, F;Yang, W;Cullen, DK;
    Skeletal muscle
    Species: Human hepegivirus
    Sample Types: Whole Cells
    Applications: Bioassay
  3. A phenotypic screening platform for identifying chemical modulators of astrocyte reactivity
    Authors: Clayton, BLL;Kristell, JD;Allan, KC;Cohn, EF;Karl, M;Jerome, AD;Garrison, E;Maeno-Hikichi, Y;Sturno, AM;Kerr, A;Shick, HE;Sepeda, JA;Freundt, EC;Sas, AR;Segal, BM;Miller, RH;Tesar, PJ;
    Nature neuroscience
    Species: Human hepegivirus
    Sample Types: Whole Cells
    Applications: Bioassay
  4. GWAS-identified hyperuricemia-associated IGF1R variant rs6598541 has a limited role in urate mediated inflammation in human mononuclear cells
    Authors: Gaal, OI;Liu, R;Marginean, D;Badii, M;Cab?u, G;Hotea, I;Nica, V;Colcear, D;HINT Consortium, ;Pamfil, C;Merriman, TR;Rednic, S;Popp, RA;Cri?an, TO;Joosten, LAB;
    Scientific reports
    Species: Human hepegivirus
    Sample Types: Whole Cells
    Applications: Bioassay
  5. Monomerization of TDP-43 is a key determinant for inducing TDP-43 pathology in amyotrophic lateral sclerosis
    Authors: Oiwa, K;Watanabe, S;Onodera, K;Iguchi, Y;Kinoshita, Y;Komine, O;Sobue, A;Okada, Y;Katsuno, M;Yamanaka, K;
    Science advances
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  6. Neuronal and Astrocyte Insulin-like Growth Factor-1 Signaling Differentially Modulates Ischemic Stroke Damage
    Authors: CA Hayes, NI Morgan, KC Thomas, MJ Pushie, A Vijayasank, BG Ashmore, K Wontor, MA De Leon, NM Ashpole
    bioRxiv : the preprint server for biology, 2023-04-02;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Bioassay
  7. Generation of three induced Pluripotent Stem Cell lines from individuals with Hypomyelination with Atrophy of Basal Ganglia and Cerebellum caused by a c.745G>A (p.D249N) autosomal dominant mutation in TUBB4A
    Authors: AA Almad, L Garcia, A Takanohash, A Gagne, W Yang, J Ann McGuir, D French, A Vanderver
    Stem Cell Research, 2023-03-26;69(0):103083.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  8. Pervasive environmental chemicals impair oligodendrocyte development
    Authors: EF Cohn, BLL Clayton, M Madhavan, S Yacoub, Y Federov, K Paul-Fried, TJ Shafer, PJ Tesar
    bioRxiv : the preprint server for biology, 2023-02-12;0(0):.
    Species: Human, Mouse
    Sample Types: Organoid, Whole Cells
    Applications: Bioassay
  9. A Potent and Selective CDKL5/GSK3 Chemical Probe is Neuroprotective
    Authors: HW Ong, Y Liang, W Richardson, ER Lowry, CI Wells, X Chen, M Silvestre, K Dempster, JA Silvaroli, JL Smith, H Wichterle, NS Pabla, SK Ultanir, AN Bullock, DH Drewry, AD Axtman
    bioRxiv : the preprint server for biology, 2023-02-10;0(0):.
    Species: Human
    Sample Types: Organoid
    Applications: Bioassay
  10. Extracellular Vesicle Treatment Alleviates Neurodevelopmental and Neurodegenerative Pathology in Cortical Spheroid Model of Down Syndrome
    Authors: NB Campbell, Y Patel, TL Moore, M Medalla, E Zeldich
    International Journal of Molecular Sciences, 2023-02-09;24(4):.
    Species: Human
    Sample Types: Spheroid
    Applications: Bioassay
  11. Binucleated human bone marrow-derived mesenchymal cells can be formed during neural-like differentiation with independence of any cell fusion events
    Authors: C Bueno, M Blanquer, D García-Ber, S Martínez, JM Moraleda
    Scientific Reports, 2022-11-30;12(1):20615.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  12. Establishment of the iPSC line CUIMCi005-A from a patient with Stargardt disease for retinal organoid culture
    Authors: PY Su, W Lee, J Zernant, SH Tsang, T Nagasaki, B Corneo, R Allikmets
    Oncogene, 2022-11-14;65(0):102973.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  13. Insulin-like growth factor 1 and the hormonal mediation of sibling rivalry
    Authors: M Ridenour, LJ Spicer, JL Grindstaff
    General and comparative endocrinology, 2022-11-07;330(0):114163.
    Species: Eastern Bluebirds
    Sample Types: Plasma
    Applications: Bioassay
  14. Membrane Attack Complex Mediates Retinal Pigment Epithelium Cell Death in Stargardt Macular Degeneration
    Authors: ESY Ng, N Kady, J Hu, A Dave, Z Jiang, J Pei, MB Gorin, A Matynia, RA Radu
    Cells, 2022-11-02;11(21):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  15. The accumulation of miR-125b-5p is indispensable for efficient erythroblast enucleation
    Authors: F Fang, L Xu, L Liang, M Qu, H Yao, W Yue, L Chen, D Chen, Z Fan, L He, X Nan, H Zhang, X Xie, X Pei
    Cell Death & Disease, 2022-10-21;13(10):886.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  16. Transcriptional dynamics of murine motor neuron maturation in vivo and in vitro
    Authors: T Patel, J Hammelman, S Aziz, S Jang, M Closser, TL Michaels, JA Blum, DK Gifford, H Wichterle
    Nature Communications, 2022-09-15;13(1):5427.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  17. GASP1 enhances malignant phenotypes of breast cancer cells and decreases their response to paclitaxel by forming a vicious cycle with IGF1/IGF1R signaling pathway
    Authors: Z Liu, D Meng, J Wang, H Cao, P Feng, S Wu, N Wang, C Dang, P Hou, P Xia
    Cell Death & Disease, 2022-08-30;13(8):751.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  18. Midkine expression by stem-like tumor cells drives persistence to mTOR inhibition and an immune-suppressive microenvironment
    Authors: Y Tang, DJ Kwiatkowsk, EP Henske
    Nature Communications, 2022-08-26;13(1):5018.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  19. Oligodendrocyte differentiation alters tRNA modifications and codon optimality-mediated mRNA decay
    Authors: S Martin, KC Allan, O Pinkard, T Sweet, PJ Tesar, J Coller
    Nature Communications, 2022-08-25;13(1):5003.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  20. Hormone regulation of thrombospondin-1 mRNA in porcine granulosa cells in vitro
    Authors: LJ Spicer, JR Evans, NB Schreiber
    Oncogene, 2022-07-26;244(0):107048.
    Species: Porcine
    Sample Types: Whole Cells
    Applications: Bioassay
  21. Non-coding de novo mutations in chromatin interactions are implicated in autism spectrum disorder
    Authors: IB Kim, T Lee, J Lee, J Kim, S Lee, IG Koh, JH Kim, JY An, H Lee, WK Kim, YS Ju, Y Cho, SJ Yu, SA Kim, M Oh, DW Han, E Kim, JK Choi, HJ Yoo, JH Lee
    Oncogene, 2022-07-15;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  22. RRM2 enhances MYCN-driven neuroblastoma formation and acts as a synergistic target with CHK1 inhibition
    Authors: C Nunes, L Depestel, L Mus, KM Keller, L Delhaye, A Louwagie, M Rishfi, A Whale, N Kara, SR Andrews, F Dela Cruz, D You, A Siddiquee, CT Cologna, S De Craemer, E Dolman, C Bartenhage, F De Vloed, E Sanders, A Eggermont, SL Bekaert, W Van Loocke, JW Bek, G Dewyn, S Loontiens, G Van Isterd, B Decaesteke, L Tilleman, F Van Nieuwe, V Vermeirsse, C Van Neste, B Ghesquiere, S Goossens, S Eyckerman, K De Preter, M Fischer, J Houseley, J Molenaar, B De Wilde, SS Roberts, K Durinck, F Speleman
    Science Advances, 2022-07-13;8(28):eabn1382.
    Species: Human
    Sample Types: Organoids
    Applications: Bioassay
  23. Transcriptional Profiling of Insulin-like Growth Factor Signaling Components in Embryonic Lung Development and Idiopathic Pulmonary Fibrosis
    Authors: V Kheirollah, A Khadim, G Kiliaris, M Korfei, MM Barroso, I Alexopoulo, AI Vazquez-Ar, M Wygrecka, C Ruppert, A Guenther, W Seeger, S Herold, E El Agha
    Cells, 2022-06-20;11(12):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  24. Kir4.2 Potassium Channels in Retinal Pigment Epithelial Cells In Vitro: Contribution to Cell Viability and Proliferation, and Down-Regulation by Vascular Endothelial Growth Factor
    Authors: MC Beer, H Kuhrt, L Kohen, P Wiedemann, A Bringmann, M Hollborn
    Biomolecules, 2022-06-18;12(6):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  25. Mutations in ALK signaling pathways conferring resistance to ALK inhibitor treatment lead to collateral vulnerabilities in neuroblastoma cells
    Authors: M Berlak, E Tucker, M Dorel, A Winkler, A McGearey, E Rodriguez-, BM da Costa, K Barker, E Fyle, E Calton, S Eising, K Ober, D Hughes, E Koutrouman, P Carter, R Stankunait, P Proszek, N Jain, C Rosswog, H Dorado-Gar, JJ Molenaar, M Hubank, G Barone, J Anderson, P Lang, HE Deubzer, A Künkele, M Fischer, A Eggert, C Kloft, AG Henssen, M Boettcher, F Hertwig, N Blüthgen, L Chesler, JH Schulte
    Molecular Cancer, 2022-06-10;21(1):126.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  26. Generation of hiPSC-Derived Skeletal Muscle Cells: Exploiting the Potential of Skeletal Muscle-Derived hiPSCs
    Authors: E Metzler, H Escobar, DY Sunaga-Fra, S Sauer, S Diecke, S Spuler
    Biomedicines, 2022-05-23;10(5):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  27. Molecular Signature of Neuroinflammation Induced in Cytokine-Stimulated Human Cortical Spheroids
    Authors: KMA De Kleijn, KR Straasheij, WA Zuure, GJM Martens
    Biomedicines, 2022-04-29;10(5):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  28. Identification of a retinoic acid-dependent haemogenic endothelial progenitor from human pluripotent stem cells
    Authors: SA Luff, JP Creamer, S Valsoni, C Dege, R Scarfò, A Dacunto, S Cascione, LN Randolph, E Cavalca, I Merelli, SA Morris, A Ditadi, CM Sturgeon
    Nature Cell Biology, 2022-04-28;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  29. Physical and functional interactome atlas of human receptor tyrosine kinases.
    Authors: Salokas K, Liu X, Ohman T, Chowdhury I, Gawriyski L, Keskitalo S, Varjosalo M
    EMBO Rep, 2022-04-05;23(6):e54041.
    Species: Human
    Sample Types: Transfected Whole Cells
    Applications: Bioassay
  30. Biomarker Changes in Response to a 12-Week Supplementation of an Oral Nutritional Supplement Enriched with Protein, Vitamin D and HMB in Malnourished Community Dwelling Older Adults with Sarcopenia
    Authors: SL Pereira, ME Shoemaker, S Gawel, GJ Davis, M Luo, VA Mustad, JT Cramer
    Nutrients, 2022-03-11;14(6):.
    Species: Human
    Sample Types: Plasma
    Applications: Bioassay
  31. Generation and characterization of motor neuron progenitors and motor neurons using metachromatic leukodystrophy-induced pluripotent stem cells
    Authors: MA Hossain, M Hasegawa-O, Y Manome, M Igarashi, C Wu, K Suzuki, J Igarashi, T Iwamoto, HJ Okano, Y Eto
    Oncogene, 2022-02-21;31(0):100852.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  32. A clinically compatible drug-screening platform based on organotypic cultures identifies vulnerabilities to prevent and treat brain metastasis
    Authors: L Zhu, D Retana, P García-Góm, L Álvaro-Esp, N Priego, M Masmudi-Ma, N Yebra, L Miarka, E Hernández-, C Blanco-Apa, S Martínez, C Sobrino, N Ajenjo, MJ Artiga, E Ortega-Pai, R Torres-Rui, S Rodríguez-, RENACER, R Soffietti, L Bertero, P Cassoni, T Weiss, J Muñoz, JM Sepúlveda, P González-L, L Jiménez-Ro, LM Moreno, O Esteban, Á Pérez-Núñe, A Hernández-, O Toldos, Y Ruano, L Alcázar, G Blasco, J Fernández-, E Caleiras, M Lafarga, D Megías, O Graña-Cast, C Nör, MD Taylor, LS Young, D Varešlija, N Cosgrove, FJ Couch, L Cussó, M Desco, S Mouron, M Quintela-F, M Weller, J Pastor, M Valiente
    Embo Molecular Medicine, 2022-02-17;0(0):e14552.
    Species: Human
    Sample Types: Whole Tissue
    Applications: Bioassay
  33. Insulin-like Growth Factor 1 Promotes Cell Proliferation by Downregulation of G-Protein-Coupled Receptor 17 Expression via PI3K/Akt/FoxO1 Signaling in SK-N-SH Cells
    Authors: KN Lin, K Zhang, W Zhao, SY Huang, H Li
    International Journal of Molecular Sciences, 2022-01-28;23(3):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  34. MGE-Like Neural Progenitor Cell Survival and Expression of Parvalbumin and Proenkephalin in a Jaundiced Rat Model of Kernicterus
    Authors: FC Yang, JL Vivian, C Traxler, SM Shapiro, JA Stanford
    Cell Transplantation, 2022-01-01;31(0):9636897221101.
    Species: Human
    Sample Types: Embryoid Bodies
    Applications: Bioassay
  35. Derivation and characterization of the induced pluripotent stem cell line CUIMCi004-A from a patient with a novel frameshift variant in exon 18a of OCRL
    Authors: G Iannello, A Patel, D Sirabella, B Corneo, VV Thaker
    Stem Cell Research, 2021-12-23;59(0):102635.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  36. Generation of Primordial Germ Cell-like Cells from iPSCs Derived from Turner Syndrome Patients
    Authors: AF de Souza, FF Bressan, NCG Pieri, RC Botigelli, T Revay, SK Haddad, DT Covas, ES Ramos, WA King, FV Meirelles
    Cells, 2021-11-10;10(11):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  37. Development of Functional Thyroid C Cell-like Cells from Human Pluripotent Cells in 2D and in 3D Scaffolds
    Authors: KD Abu-Bonsra, DF Newgreen, M Dottori
    Cells, 2021-10-26;10(11):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  38. Dysregulated overexpression of Sox9 induces fibroblast activation in pulmonary fibrosis
    Authors: PR Gajjala, RK Kasam, D Soundarara, D Sinner, SK Huang, AG Jegga, SK Madala
    JCI Insight, 2021-10-22;0(0):.
    Species: Human, Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  39. The Use of Human Serum Samples to Study Malignant Transformation: A Pilot Study
    Authors: AN Holowatyj, B Gigic, CA Warby, J Ose, T Lin, P Schrotz-Ki, CM Ulrich, JJ Bernard
    Cells, 2021-10-06;10(10):.
    Species: Human
    Sample Types: Serum
    Applications: Bioassay
  40. Thrombolysis by PLAT/tPA increases serum free IGF1 leading to a decrease of deleterious autophagy following brain ischemia
    Authors: AM Thiebaut, I Buendia, V Ginet, E Lemarchand, MB Boudjadja, Y Hommet, L Lebouvier, C Lechevalli, M Maillasson, E Hedou, N Déglon, F Oury, M Rubio, J Montaner, J Puyal, D Vivien, BD Roussel
    Autophagy, 2021-09-14;0(0):1-21.
    Species: Human
    Sample Types: Recombinant Proteins
    Applications: Bioassay
  41. Neuroblastoma and DIPG Organoid Coculture System for Personalized Assessment of Novel Anticancer Immunotherapies
    Authors: W M Kholosy, M Derieppe, F van den Ha, K Ober, Y Su, L Custers, L Schild, L M J van Zo, L M Wellens, H R Ariese, CL Szanto, J Wienke, MP Dierselhui, D van Vuurde, EM Dolman, JJ Molenaar
    Journal of personalized medicine, 2021-08-30;11(9):.
    Species: Human
    Sample Types: Organoids
    Applications: Bioassay
  42. PI3K/AKT phosphorylation activates ERRalpha by upregulating PGC?1alpha and PGC?1beta in gallbladder cancer
    Authors: L Wang, M Yang, H Jin
    Molecular Medicine Reports, 2021-06-29;24(2):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  43. Generation of the iPSC line CUIMCi003-A derived from a patient with severe early onset obesity
    Authors: G Iannello, A Patel, D Sirabella, B Corneo, V Thaker
    Stem Cell Research, 2021-06-21;54(0):102432.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  44. Transdifferentiation of Human Fibroblasts into Skeletal Muscle Cells: Optimization and Assembly into Engineered Tissue Constructs through Biological Ligands
    Authors: KMA Abdel-Raou, R Rezgui, C Stefanini, JCM Teo, N Christofor
    Biology, 2021-06-16;10(6):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  45. IGF1-mediated HOXA13 overexpression promotes colorectal cancer metastasis through upregulating ACLY and IGF1R
    Authors: C Qiao, W Huang, J Chen, W Feng, T Zhang, Y Wang, D Liu, X Ji, M Xie, M Sun, D Fan, K Wu, L Xia
    Cell Death & Disease, 2021-06-01;12(6):564.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  46. Generation of two human induced pluripotent stem cell (hiPSC) lines derived from unrelated Marfan Syndrome patients
    Authors: J Borsoi, M Morato-Mar, F de Araújo, L Assis Pere, LE Farinha-Ar, R Delgado Sa, AB Alvarez Pe, L Veiga Pere
    Stem Cell Research, 2021-05-25;54(0):102407.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  47. Dual Role of Insulin-Like Growth Factor (IGF)-I in American Tegumentary Leishmaniasis
    Authors: C de O Mende, C Lopes-Siqu, F Pettito-As, M Pereira-Ol, MP de Oliveir, C Pirmez, AM Da-Cruz, H Goto
    Journal of Immunology Research, 2021-03-29;2021(0):6657785.
    Species: L. braziliensis
    Sample Types: Whole Cells
    Applications: Bioassay
  48. Effects of selected hormones and their combination on progesterone and estradiol production and proliferation of feline granulosa cells cultured in�vitro
    Authors: M Chiara Per, N Bellitto, ERS Maylem, F Caloni, LJ Spicer
    Theriogenology, 2021-03-28;168(0):1-12.
    Species: Feline
    Sample Types: Whole Cells
    Applications: Bioassay
  49. Transcriptional networks identify synaptotagmin-like 3 as a regulator of cortical neuronal migration during early neurodevelopment
    Authors: X Dong, L Yang, K Liu, X Ji, C Tang, W Li, L Ma, Y Mei, T Peng, B Feng, Z Wu, Q Tang, Y Gao, K Yan, W Zhou, M Xiong
    Cell Reports, 2021-03-02;34(9):108802.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  50. Defining the epitope of a blood-brain barrier crossing single domain antibody specific for the type 1 insulin-like growth factor receptor
    Authors: J Sheff, P Wang, P Xu, M Arbour, L Masson, H van Faasse, G Hussack, K Kemmerich, E Brunette, D Stanimirov, JJ Hill, J Kelly, F Ni
    Scientific Reports, 2021-02-19;11(1):4284.
    Species: Human
    Sample Types: Whole Cells
    Applications: Surface Plasmon Resonance
  51. Global transcriptome profile of the developmental principles of in vitro iPSC-to-motor neuron differentiation
    Authors: E Solomon, K Davis-Ande, B Hovde, S Micheva-Vi, JF Harris, S Twary, R Iyer
    BMC molecular and cell biology, 2021-02-18;22(1):13.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  52. Inhibition of longevity regulator PAPP-A modulates tissue homeostasis via restraint of mesenchymal stromal cells
    Authors: M Mohrin, J Liu, J Zavala-Sol, S Bhargava, J Maxwell Tr, A Brito, D Hu, D Brooks, G Koukos, L Alabdulaal, JS Paw, K Hake, G Kolumam, ML Bouxsein, R Baron, Y Kutskova, A Freund
    Aging Cell, 2021-02-09;0(0):e13313.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  53. Chondrogenesis of human amniotic fluid stem cells in Chitosan-Xanthan scaffold for cartilage tissue engineering
    Authors: CC Zuliani, II Damas, KC Andrade, CB Westin, ÂM Moraes, IB Coimbra
    Scientific Reports, 2021-02-04;11(1):3063.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  54. The translocon-associated protein (TRAP) complex regulates quality control of N-linked glycosylation during ER stress
    Authors: C Phoomak, W Cui, TJ Hayman, SH Yu, P Zhao, L Wells, R Steet, JN Contessa
    Science Advances, 2021-01-15;7(3):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  55. ApoE-Isoform-Dependent SARS-CoV-2 Neurotropism and Cellular Response
    Authors: C Wang, M Zhang, G Garcia, E Tian, Q Cui, X Chen, G Sun, J Wang, V Arumugaswa, Y Shi
    Cell Stem Cell, 2021-01-04;28(2):331-342.e5.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  56. Establishment of a New Device for Electrical Stimulation of Non-Degenerative Cartilage Cells In Vitro
    Authors: S Krueger, A Riess, A Jonitz-Hei, A Weizel, A Seyfarth, H Seitz, R Bader
    International Journal of Molecular Sciences, 2021-01-01;22(1):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  57. Endothelial Reprogramming by Disturbed Flow Revealed by Single-Cell RNA and Chromatin Accessibility Study
    Authors: A Andueza, S Kumar, J Kim, DW Kang, HL Mumme, JI Perez, N Villa-Roel, H Jo
    Cell Reports, 2020-12-15;33(11):108491.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  58. Insulin-like growth factor 1 partially rescues early developmental defects caused by SHANK2 knockdown in human neurons
    Authors: ST Chen, WJ Lai, WJ Zhang, QP Chen, LB Zhou, KF So, LL Shi
    Neural Regen Res, 2020-12-01;15(12):2335-2343.
    Species: Human
    Sample Types: Transfected Whole Cells
    Applications: Bioassay
  59. Proto-oncogene Src links lipogenesis via lipin-1 to breast cancer malignancy
    Authors: L Song, Z Liu, HH Hu, Y Yang, TY Li, ZZ Lin, J Ye, J Chen, X Huang, DT Liu, J Zhou, Y Shi, H Zhao, C Xie, L Chen, E Song, SY Lin, SC Lin
    Nat Commun, 2020-11-17;11(1):5842.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  60. Non-canonical Targets of HIF1a Impair Oligodendrocyte Progenitor Cell Function
    Authors: KC Allan, LR Hu, MA Scavuzzo, AR Morton, AS Gevorgyan, EF Cohn, BLL Clayton, IR Bederman, S Hung, CF Bartels, M Madhavan, PJ Tesar
    Cell Stem Cell, 2020-10-21;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  61. Modulation of Rab7a-mediated growth factor receptor trafficking inhibits islet beta cell apoptosis and autophagy under conditions of metabolic stress
    Authors: NV Hewawasam, F Lhaf, HA Taylor, K Viloria, A Austin, A King, P Jones, L Jones, MD Turner, NJ Hill
    Sci Rep, 2020-09-25;10(1):15741.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  62. IGF-1R stimulation alters microglial polarization via TLR4/NF-kappaB pathway after cerebral hemorrhage in mice
    Authors: Z Sun, K Wu, L Gu, L Huang, Q Zhuge, S Yang, Z Wang
    Brain Res. Bull., 2020-08-29;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Bioassay
  63. Insulin-like growth factor 1-receptor signaling stimulates GRP78 expression through the PI3K/AKT/mTOR/ATF4 axis
    Authors: DP Ha, AS Lee
    Cell. Signal., 2020-08-14;75(0):109736.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  64. Modelling West Nile Virus and Usutu Virus Pathogenicity in Human Neural Stem Cells
    Authors: S Riccetti, A Sinigaglia, G Desole, N Nowotny, M Trevisan, L Barzon
    Viruses, 2020-08-12;12(8):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  65. Protein tyrosine phosphatase 1B as a therapeutic target for Graves' orbitopathy in an in vitro model
    Authors: HJ Byeon, JY Kim, J Ko, EJ Lee, K Don, JS Yoon
    PLoS ONE, 2020-08-06;15(8):e0237015.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay, Cell Culture
  66. Patient-derived ovarian cancer organoids capture the genomic profiles of primary tumours applicable for drug sensitivity and resistance testing
    Authors: Y Nanki, T Chiyoda, A Hirasawa, A Ookubo, M Itoh, M Ueno, T Akahane, K Kameyama, W Yamagami, F Kataoka, D Aoki
    Sci Rep, 2020-07-28;10(1):12581.
    Species: Human
    Sample Types: Organoid
    Applications: Bioassay
  67. Controlled Delivery of Insulin-like Growth Factor-1 from Bioactive Glass-Incorporated Alginate-Poloxamer/Silk Fibroin Hydrogels
    Authors: Q Min, X Yu, J Liu, Y Zhang, Y Wan, J Wu
    Pharmaceutics, 2020-06-20;12(6):.
    Species: N/A
    Sample Types: Nanoparticles
    Applications: Bioassay
  68. Mapping developmental trajectories and subtype diversity of normal and glaucomatous human retinal ganglion cells by single-cell transcriptome analysis
    Authors: P Teotia, M Niu, I Ahmad
    Stem Cells, 2020-06-18;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  69. Intracellular Insulin-like growth factor binding protein 2 (IGFBP2) contributes to the senescence of keratinocytes in psoriasis by stabilizing cytoplasmic p21
    Authors: L Mercurio, D Lulli, F Mascia, E Dellambra, C Scarponi, M Morelli, C Valente, ML Carbone, S Pallotta, G Girolomoni, C Albanesi, S Pastore, S Madonna
    Aging (Albany NY), 2020-04-17;12(8):6823-6851.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  70. Different regulation of lipogenesis in sebocytes and subcutaneous preadipocytes in hamsters in vitro
    Authors: T Sato, F Shibata, T Koiwai, N Akimoto
    Biochem Biophys Rep, 2020-04-10;22(0):100761.
    Species: Hamster
    Sample Types: Whole Cells
    Applications: Cell Culture
  71. Unveiling synapse pathology in spinal bulbar muscular atrophy by genome-wide transcriptome analysis of purified motor neurons derived from disease specific iPSCs
    Authors: K Onodera, D Shimojo, Y Ishihara, M Yano, F Miya, H Banno, N Kuzumaki, T Ito, R Okada, B de Araújo, M Ohyama, M Yoshida, T Tsunoda, M Katsuno, M Doyu, G Sobue, H Okano, Y Okada
    Mol Brain, 2020-02-19;13(1):18.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  72. Establishment of SLC15A1/PEPT1-Knockout Human-Induced Pluripotent Stem Cell Line for Intestinal Drug Absorption Studies
    Authors: K Kawai, R Negoro, M Ichikawa, T Yamashita, S Deguchi, K Harada, K Hirata, K Takayama, H Mizuguchi
    Mol Ther Methods Clin Dev, 2019-11-21;17(0):49-57.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  73. Reprogramming of Fibroblasts to Oligodendrocyte Progenitor-like Cells Using CRISPR/Cas9-Based Synthetic Transcription Factors
    Authors: M Matjusaiti, LJ Wagstaff, A Martella, B Baranowski, C Blin, S Gogolok, A Williams, SM Pollard
    Stem Cell Reports, 2019-11-07;13(6):1053-1067.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  74. Re-Differentiation Capacity of Human Chondrocytes in Vitro Following Electrical Stimulation with Capacitively Coupled Fields
    Authors: S Krueger, S Achilles, J Zimmermann, T Tischer, R Bader, A Jonitz-Hei
    J Clin Med, 2019-10-24;8(11):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  75. Oligodendrocyte Intrinsic miR-27a Controls Myelination and Remyelination
    Authors: A Tripathi, C Volsko, JP Garcia, E Agirre, KC Allan, PJ Tesar, BD Trapp, G Castelo-Br, FJ Sim, R Dutta
    Cell Rep, 2019-10-22;29(4):904-919.e9.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  76. V2a interneuron differentiation from mouse and human pluripotent stem cells
    Authors: JC Butts, N Iyer, N White, R Thompson, S Sakiyama-E, TC McDevitt
    Nat Protoc, 2019-10-18;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  77. IGF-1R Inhibition Suppresses Cell Proliferation and Increases Radiosensitivity in Nasopharyngeal Carcinoma Cells
    Authors: Z Wang, G Liu, J Mao, M Xie, M Zhao, X Guo, S Liang, H Li, X Li, R Wang
    Mediators Inflamm., 2019-07-31;2019(0):5497467.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  78. Effects of N-carbamylglutamate and arginine on steroidogenesis and proliferation of pig granulosa cells in vitro
    Authors: T Feng, AA DeVore, MC Perego, BC Morrell, LJ Spicer
    Anim. Reprod. Sci., 2019-07-26;209(0):106138.
    Species: Porcine
    Sample Types: Whole Cells
    Applications: Bioassay
  79. Dysregulated Glial Differentiation in Schizophrenia May Be Relieved by Suppression of SMAD4- and REST-Dependent Signaling
    Authors: Z Liu, M Osipovitch, A Benraiss, NPT Huynh, R Foti, J Bates, D Chandler-M, RL Findling, PJ Tesar, M Nedergaard, MS Windrem, SA Goldman
    Cell Rep, 2019-06-25;27(13):3832-3843.e6.
    Species: Human
    Sample Types: Organoid
    Applications: Bioassay
  80. Comparison of the effect of growth factors on chondrogenesis of canine mesenchymal stem cells
    Authors: K Endo, N Fujita, T Nakagawa, R Nishimura
    J. Vet. Med. Sci., 2019-06-04;0(0):.
    Species: Human
    Sample Types: Whole Cell
    Applications: Bioassay
  81. Establishment of an erythroid progenitor cell line capable of enucleation achieved with an inducible c-Myc vector
    Authors: S Mayers, PD Moço, T Maqbool, PN Silva, DM Kilkenny, J Audet
    BMC Biotechnol., 2019-04-15;19(1):21.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  82. Essential Gene Profiles for Human Pluripotent Stem Cells Identify Uncharacterized Genes and Substrate Dependencies
    Authors: B Mair, J Tomic, SN Masud, P Tonge, A Weiss, M Usaj, AHY Tong, JJ Kwan, KR Brown, E Titus, M Atkins, KSK Chan, L Munsie, A Habsid, H Han, M Kennedy, B Cohen, G Keller, J Moffat
    Cell Rep, 2019-04-09;27(2):599-615.e12.
    Species: Human
    Sample Types: cell culture
    Applications: Differentiation, Differentiation
  83. A Potential Antitumor Effect of Dendritic Cells Fused with Cancer Stem Cells in Hepatocellular Carcinoma
    Authors: YB Pang, J He, BY Cui, S Xu, XL Li, MY Wu, R Liang, Y Feng, X Guo, XH Zhang, XL Luo
    Stem Cells Int, 2019-04-01;2019(0):5680327.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  84. Ginsenoside Rg5 induces apoptosis in human esophageal cancer cells through the phosphoinositide?3 kinase/protein kinase B signaling pathway
    Authors: D Zhang, A Wang, J Feng, Q Zhang, L Liu, H Ren
    Mol Med Rep, 2019-03-27;19(5):4019-4026.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  85. CAMKII as a therapeutic target for growth factor-induced retinal and choroidal neovascularisation
    Authors: S Ashraf, S Bell, C O'Leary, P Canning, I Micu, JA Fernandez, M O'Hare, P Barabas, H McCauley, DP Brazil, AW Stitt, JG McGeown, TM Curtis
    JCI Insight, 2019-03-21;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  86. Cellular characterization of human epicardial adipose tissue: highly expressed PAPP-A regulates insulin-like growth factor I signaling in human cardiomyocytes
    Authors: CA Conover, LK Bale, RL Frye, HV Schaff
    Physiol Rep, 2019-02-01;7(4):e14006.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  87. Selective estrogen receptor modulators enhance CNS remyelination independent of estrogen receptors
    Authors: KA Rankin, F Mei, K Kim, YA Shen, SR Mayoral, C Desponts, DS Lorrain, AJ Green, SE Baranzini, JR Chan, R Bove
    J. Neurosci., 2019-01-29;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  88. SETDB1-mediated methylation of Akt promotes its K63-linked ubiquitination and activation leading to tumorigenesis
    Authors: G Wang, J Long, Y Gao, W Zhang, F Han, C Xu, L Sun, SC Yang, J Lan, Z Hou, Z Cai, G Jin, CC Hsu, YH Wang, J Hu, TY Chen, H Li, MG Lee, HK Lin
    Nat. Cell Biol., 2019-01-28;0(0):.
    Species: Human, Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  89. Functional Assessment of Patient-Derived Retinal Pigment Epithelial Cells Edited by CRISPR/Cas9
    Authors: LP Foltz, SE Howden, JA Thomson, DO Clegg
    Int J Mol Sci, 2018-12-19;19(12):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  90. Human ESC-Derived Chimeric Mouse Models of Huntington's Disease Reveal Cell-Intrinsic Defects in Glial Progenitor Cell Differentiation
    Authors: M Osipovitch, A Asenjo Mar, JN Mariani, A Cornwell, S Dhaliwal, L Zou, D Chandler-M, S Wang, X Li, SJ Benraiss, R Agate, A Lampp, A Benraiss, MS Windrem, SA Goldman
    Cell Stem Cell, 2018-12-13;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  91. Theaflavins prevent cartilage degeneration via AKT/FOXO3 signaling in�vitro
    Authors: J Li, J Zheng
    Mol Med Rep, 2018-12-12;19(2):821-830.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  92. Efficient Generation of Small Intestinal Epithelial-like Cells from Human iPSCs for Drug Absorption and Metabolism Studies
    Authors: R Negoro, K Takayama, K Kawai, K Harada, F Sakurai, K Hirata, H Mizuguchi
    Stem Cell Reports, 2018-11-21;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  93. TBX2 is a neuroblastoma core regulatory circuitry component enhancing MYCN/FOXM1 reactivation of DREAM targets
    Authors: B Decaesteke, G Denecker, C Van Neste, EM Dolman, W Van Loocke, M Gartlgrube, C Nunes, F De Vloed, P Depuydt, K Verboom, D Rombaut, S Loontiens, J De Wyn, WM Kholosy, B Koopmans, AHW Essing, C Herrmann, D Dreidax, K Durinck, D Deforce, F van Nieuwe, A Henssen, R Versteeg, V Boeva, G Schleierma, J van Nes, P Mestdagh, S Vanhauwaer, JH Schulte, F Westermann, JJ Molenaar, K De Preter, F Speleman
    Nat Commun, 2018-11-19;9(1):4866.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  94. Urolithin A, a novel natural compound to target PI3K/AKT/mTOR pathway in pancreatic cancer
    Authors: TM Totiger, S Srinivasan, VR Jala, P Lamichhane, AR Dosch, AA Gaidarski, C Joshi, S Rangappa, J Castellano, PK Vemula, X Chen, D Kwon, N Kashikar, M VanSaun, NB Merchant, NS Nagathihal
    Mol. Cancer Ther., 2018-11-07;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  95. Involvement of the capsular GalXM-induced IL-17 cytokine in the control of Cryptococcus neoformans infection
    Authors: IF LaRocque-d, JDB Rocha, MP Nunes, PAV Oliveira, DO Nascimento, L Freire-de-, CM Takiya, A Morrot, D Decote-Ric, JO Previato, GA DosReis, L Mendonça-P, CG Freire-de-
    Sci Rep, 2018-11-06;8(1):16378.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  96. VGF nerve growth factor inducible is involved in retinal ganglion cells death induced by optic nerve crush
    Authors: H Takeuchi, S Inagaki, W Morozumi, Y Nakano, Y Inoue, Y Kuse, T Mizoguchi, S Nakamura, M Funato, H Kaneko, H Hara, M Shimazawa
    Sci Rep, 2018-11-06;8(1):16443.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  97. Generation and characterization of two human induced pluripotent stem cell (hiPSC) lines homozygous for the Apolipoprotein e4 (APOE4) risk variant-Alzheimer's disease (ASUi005-A) and healthy non-demented control (ASUi006-A)
    Authors: N Brookhouse, P Zhang, R Caselli, JJ Kim, DA Brafman
    Stem Cell Res, 2018-09-21;32(0):145-149.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  98. Development of a Graphene Oxide-Incorporated Polydimethylsiloxane Membrane with Hexagonal Micropillars
    Authors: YY Lin, Y Chien, JH Chuang, CC Chang, YP Yang, YH Lai, WL Lo, KH Chien, TI Huo, CY Wang
    Int J Mol Sci, 2018-08-25;19(9):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  99. Insulin-Like Growth Factor-I as an Effector Element of the Cytokine IL-4 in the Development of a Leishmania major Infection
    Authors: LC Reis, EM Ramos-Sanc, F Petitto-As, AH Nerland, M Hernandez-, F Selheim, LM Floeter-Wi, H Goto
    Mediators Inflamm., 2018-07-29;2018(0):9787128.
    Species: Mouse
    Sample Types: In Vivo
  100. The ubiquitin ligase UBR5 suppresses proteostasis collapse in pluripotent stem cells from Huntington's disease patients
    Authors: S Koyuncu, I Saez, HJ Lee, R Gutierrez-, W Pokrzywa, A Fatima, T Hoppe, D Vilchez
    Nat Commun, 2018-07-23;9(1):2886.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  101. Short Term Development and Fate of MGE-Like Neural Progenitor Cells in Jaundiced and Non-Jaundiced Rat Brain
    Authors: FC Yang, J Draper, PG Smith, JL Vivian, SM Shapiro, JA Stanford
    Cell Transplant, 2018-05-30;0(0):9636897187663.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  102. Generation of Human Induced Pluripotent Stem Cells Using a Defined, Feeder-Free Reprogramming System.
    Authors: Park S, Mostoslavsky G
    Curr Protoc Stem Cell Biol, 2018-05-04;45(1):e48.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  103. Celastrol Attenuates the Invasion and Migration and Augments the Anticancer Effects of Bortezomib in a Xenograft Mouse Model of Multiple Myeloma
    Authors: MK Shanmugam, KS Ahn, JH Lee, R Kannaiyan, N Mustafa, KA Manu, KS Siveen, G Sethi, WJ Chng, AP Kumar
    Front Pharmacol, 2018-05-03;9(0):365.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  104. An inactivating mutation in the histone deacetylase SIRT6 causes human perinatal lethality
    Authors: CM Ferrer, M Alders, AV Postma, S Park, MA Klein, M Cetinbas, E Pajkrt, A Glas, S van Koning, VM Christoffe, MMAM Mannens, L Knegt, JP Etchegaray, RI Sadreyev, JM Denu, G Mostoslavs, MC van Maarle, R Mostoslavs
    Genes Dev., 2018-03-19;32(5):373-388.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  105. Modulation of hyaluronan polymer size regulates proliferation of perimysial fibroblasts in thyroid eye disease
    Authors: R Ma, Q Li, Z Wang, Y Yuan, L Gan, J Qian
    Biochem. Biophys. Res. Commun., 2018-02-05;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  106. Chromosomal instability during neurogenesis in Huntington's disease
    Authors: A Ruzo, GF Croft, JJ Metzger, S Galgoczi, LJ Gerber, C Pellegrini, H Wang, M Fenner, S Tse, A Marks, C Nchako, AH Brivanlou
    Development, 2018-01-29;145(2):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Differentiation, Differentiation
  107. Fast neurogenesis from carotid body quiescent neuroblasts accelerates adaptation to hypoxia
    Authors: V Sobrino, P González-R, V Annese, J López-Barn, R Pardal
    EMBO Rep., 2018-01-15;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  108. In Vitro Regeneration of Patient-specific Ear-shaped Cartilage and Its First Clinical Application for Auricular Reconstruction
    Authors: G Zhou, H Jiang, Z Yin, Y Liu, Q Zhang, C Zhang, B Pan, J Zhou, X Zhou, H Sun, D Li, A He, Z Zhang, W Zhang, W Liu, Y Cao
    EBioMedicine, 2018-01-13;28(0):287-302.
    Species: Human
    Sample Types: Complex Sample Type
    Applications: Bioassay
  109. Notch transactivates Rheb to maintain the multipotency of TSC-null cells.
    Authors: Jun-Hung Cho, Bhaumik Patel, Santosh Bonala, Sasikanth Manne, Yan Zhou, Surya K Vadrevu, Jalpa Patel, Marco Peronaci, Shanawaz Ghouse, Elizabeth P Henske, Fabrice Roegiers, Krinio Giannikou, David J Kwiatkows, Hossein Mansouri, Maciej M Markiewsk, Brandon White, Magdalena Karbownic
    Nature Communications, 2017-11-29;0(0):2041-1723.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  110. Retinoic Acid-Signaling Regulates the Proliferative and Neurogenic Capacity of M�ller Glia-Derived Progenitor Cells in the Avian Retina
    Authors: L Todd, L Suarez, C Quinn, AJ Fischer
    Stem Cells, 2017-11-27;0(0):.
    Species: Chicken
    Sample Types: In Vivo
    Applications: In Vivo
  111. Expression patterns of FSHD-causing DUX4 and myogenic transcription factors PAX3 and PAX7 are spatially distinct in differentiating human stem cell cultures
    Authors: P Haynes, K Kernan, SL Zhou, DG Miller
    Skelet Muscle, 2017-06-21;7(1):13.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  112. A Collagen Cardiac Patch Incorporating Alginate Microparticles Permits the Controlled Release of HGF and IGF-1 to Enhance Cardiac Stem Cell Migration and Proliferation
    Authors: Hugh S O'Neill
    J Tissue Eng Regen Med, 2017-06-19;0(0):.
    Species: N/A
    Sample Types: Complex Sample Type
    Applications: Bioassay
  113. Transplantation of Human Embryonic Stem Cell-Derived Retinal Cells into the Subretinal Space of a Non-Human Primate
    Authors: JR Chao, DA Lamba, TR Klesert, A Torre, A Hoshino, RJ Taylor, A Jayabalu, AL Engel, TH Khuu, RK Wang, M Neitz, J Neitz, TA Reh
    Transl Vis Sci Technol, 2017-05-16;6(3):4.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  114. IL-37 induces autophagy in hepatocellular carcinoma cells by inhibiting the PI3K/AKT/mTOR pathway
    Authors: TT Li, D Zhu, T Mou, Z Guo, JL Pu, QS Chen, XF Wei, ZJ Wu
    Mol. Immunol., 2017-04-25;87(0):132-140.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  115. Atypical PKC and Notch Inhibition Differentially Modulate Cortical Interneuron Subclass Fate from Embryonic Stem Cells
    Authors: DJ Tischfield, J Kim, SA Anderson
    Stem Cell Reports, 2017-04-13;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  116. Modeling the Mutational and Phenotypic Landscapes of Pelizaeus-Merzbacher Disease with Human iPSC-Derived Oligodendrocytes
    Authors: ZS Nevin, DC Factor, RT Karl, P Douvaras, J Laukka, MS Windrem, SA Goldman, V Fossati, GM Hobson, PJ Tesar
    Am. J. Hum. Genet., 2017-03-30;100(4):617-634.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  117. Differential involvement of the microtubule cytoskeleton in Insulin Receptor Substrate-1 (IRS-1) and IRS-2 signaling to AKT determines response to microtubule disruption in breast carcinoma cells
    Authors: J Mercado-Ma, JL Clark, AJ Piper, J Janusis, LM Shaw
    J. Biol. Chem, 2017-03-20;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  118. Establishment of an induced pluripotent stem cell (iPSC) line from a 9-year old male with autism spectrum disorder (ASD)
    Authors: E Varga, C Nemes, I Bock, Z Táncos, S Berzsenyi, G Lévay, V Román, J Kobolák, A Dinnyés
    Stem Cell Res, 2017-03-18;21(0):19-22.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  119. Generation of retinal pigmented epithelium from iPSCs derived from the conjunctiva of donors with and without age related macular degeneration
    Authors: Z Geng, PJ Walsh, V Truong, C Hill, M Ebeling, RJ Kapphahn, SR Montezuma, C Yuan, H Roehrich, DA Ferrington, JR Dutton
    PLoS ONE, 2017-03-10;12(3):e0173575.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  120. Inhibition of Proliferation and Epithelial Mesenchymal Transition in Retinal Pigment Epithelial Cells by Heavy Chain-Hyaluronan/Pentraxin 3
    Authors: H He, AE Kuriyan, CW Su, M Mahabole, Y Zhang, YT Zhu, HW Flynn, JM Parel, SC Tseng
    Sci Rep, 2017-03-02;7(0):43736.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  121. Severe pre-eclampsia is associated with alterations in cytotrophoblasts of the smooth chorion
    Authors: T Garrido-Go, K Ona, M Kapidzic, M Gormley, C Simón, O Genbacev, SJ Fisher
    Development, 2017-03-01;144(5):767-777.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  122. Experimental Study of the Biological Properties of Human Embryonic Stem Cell-Derived Retinal Progenitor Cells
    Authors: J Shao, PY Zhou, GH Peng
    Sci Rep, 2017-02-13;7(0):42363.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  123. Insulin-Like Growth Factor-1 Increases the Expression of Inflammatory Biomarkers and Sebum Production in Cultured Sebocytes
    Authors: H Kim, SY Moon, MY Sohn, WJ Lee
    Ann Dermatol, 2017-02-03;29(1):20-25.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  124. Human iPSC-Derived Neural Progenitors Are an Effective Drug Discovery Model for Neurological mtDNA Disorders
    Authors: C Lorenz, P Lesimple, R Bukowiecki, A Zink, G Inak, B Mlody, M Singh, M Semtner, N Mah, K Aur‚, M Leong, O Zabiegalov, EM Lyras, V Pfiffer, B Fauler, J Eichhorst, B Wiesner, N Huebner, J Priller, T Mielke, D Meierhofer, Z Izsv k, JC Meier, F Bouillaud, J Adjaye, M Schuelke, EE Wanker, A LombŠs, A Prigione
    Cell Stem Cell, 2017-01-26;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  125. IGF-IR cooperates with ER? to inhibit breast cancer cell aggressiveness by regulating the expression and localisation of ECM molecules
    Authors: NA Afratis, P Bouris, SS Skandalis, HA Multhaupt, JR Couchman, AD Theocharis, NK Karamanos
    Sci Rep, 2017-01-12;7(0):40138.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  126. Soluble klotho binds monosialoganglioside to regulate membrane microdomains and growth factor signaling
    Authors: G Dalton, SW An, SI Al-Juboori, N Nischan, J Yoon, E Dobrinskik, DW Hilgemann, J Xie, K Luby-Phelp, JJ Kohler, L Birnbaumer, CL Huang
    Proc. Natl. Acad. Sci. U.S.A, 2017-01-09;114(4):752-757.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  127. Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity
    Authors: Ivan Carcamo-Or
    Cell Stem Cell, 2016-12-22;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  128. G protein-coupled receptor 34 in ovarian granulosa cells of cattle: changes during follicular development and potential functional implications
    Authors: L J Spicer
    Domest. Anim. Endocrinol, 2016-12-11;59(0):90-99.
    Species: Bovine
    Sample Types: Whole Cells
    Applications: Bioassay
  129. Evidence for direct effects of glyphosate on ovarian function: glyphosate influences steroidogenesis and proliferation of bovine granulosa but not theca cells in vitro
    Authors: Maria Chiara Perego
    J Appl Toxicol, 2016-12-05;0(0):.
    Species: Bovine
    Sample Types: Whole Cells
    Applications: Bioassay
  130. TGF? signaling confers sorafenib resistance via induction of multiple RTKs in hepatocellular carcinoma cells
    Authors: Tong Wu
    Mol. Carcinog., 2016-11-25;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  131. Fibroblast growth factor 9 (FGF9) regulation of cyclin D1 and cyclin-dependent kinase-4 in ovarian granulosa and theca cells of cattle
    Authors: L J Spicer
    Mol. Cell. Endocrinol., 2016-11-03;0(0):.
    Species: Bovine
    Sample Types: Whole Cells
    Applications: Bioassay
  132. The tobacco-specific carcinogen-operated calcium channel promotes lung tumorigenesis via IGF2 exocytosis in lung epithelial cells
    Nat Commun, 2016-09-26;7(0):12961.
    Species: Human
    Sample Types:
    Applications: Neutralization
  133. Polyurethane scaffolds seeded with CD34(+) cells maintain early stem cells whilst also facilitating prolonged egress of haematopoietic progenitors
    Sci Rep, 2016-08-30;6(0):32149.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  134. 3D patterned stem cell differentiation using thermo-responsive methylcellulose hydrogel molds
    Sci Rep, 2016-07-06;6(0):29408.
    Species: Human
    Sample Types:
  135. IGF1R as a Key Target in High Risk, Metastatic Medulloblastoma
    Authors: Matthew N Svalina
    Sci Rep, 2016-06-03;6(0):27012.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  136. Structural and functional investigations of the effector protein LpiR1 from Legionella pneumophila
    J Biol Chem, 2016-05-17;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  137. Application of single-cell RNA sequencing in optimizing a combinatorial therapeutic strategy in metastatic renal cell carcinoma
    Genome Biol, 2016-04-29;17(1):80.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  138. Abnormal IGF-Binding Protein Profile in the Bone Marrow of Multiple Myeloma Patients
    Authors: L Bieghs, M Brohus, IB Kristensen, N Abildgaard, M Bøgsted, HE Johnsen, CA Conover, E De Bruyne, K Vanderkerk, MT Overgaard, M Nyegaard
    PLoS ONE, 2016-04-25;11(4):e0154256.
    Species: Human
    Sample Types: Plasma
    Applications: Bioassay
  139. Metabolites involved in glycolysis and amino acid metabolism are altered in short children born small for gestational age
    Authors: Peter E Clayton
    Pediatr. Res., 2016-04-08;80(2):299-305.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  140. Tumor-Free Transplantation of Patient-Derived Induced Pluripotent Stem Cell Progeny for Customized Islet Regeneration
    Authors: Yasuhiro Ikeda
    Stem Cells Transl Med, 2016-03-17;5(5):694-702.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  141. EphrinB2 controls vessel pruning through STAT1-JNK3 signalling.
    Authors: Salvucci O, Ohnuki H, Maric D, Hou X, Li X, Yoon S, Segarra M, Eberhart C, Acker-Palmer A, Tosato G
    Nat Commun, 2015-03-26;6(0):6576.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  142. Functional EpoR pathway utilization is not detected in primary tumor cells isolated from human breast, non-small cell lung, colorectal, and ovarian tumor tissues.
    Authors: Patterson, Scott D, Rossi, John M, Paweletz, Katherin, Fitzpatrick, V Dan, Begley, C Glenn, Busse, Leigh, Elliott, Steve, McCaffery, Ian
    PLoS ONE, 2015-03-25;10(3):e0122149.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  143. Vascular niche promotes hematopoietic multipotent progenitor formation from pluripotent stem cells.
    Authors: Gori J, Butler J, Chan Y, Chandrasekaran D, Poulos M, Ginsberg M, Nolan D, Elemento O, Wood B, Adair J, Rafii S, Kiem H
    J Clin Invest, 2015-02-09;125(3):1243-54.
    Species: Primate - Macaca nemestrina (Southern Pig-tailed Macaque)
    Sample Types: Whole Cells
    Applications: Bioassay
  144. Insulin like growth factor binding protein 7 (IGFBP7) expression is linked to poor prognosis but may protect from bone disease in multiple myeloma.
    Authors: Bolomsky A, Hose D, Schreder M, Seckinger A, Lipp S, Klein B, Heintel D, Ludwig H, Zojer N
    J Hematol Oncol, 2015-02-08;8(1):10.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  145. GlcUAbeta1-3Galbeta1-3Galbeta1-4Xyl(2-O-phosphate) is the preferred substrate for chondroitin N-acetylgalactosaminyltransferase-1.
    Authors: Izumikawa T, Sato B, Mikami T, Tamura J, Igarashi M, Kitagawa H
    J Biol Chem, 2015-01-07;290(9):5438-48.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  146. Patient-derived xenografts from non-small cell lung cancer brain metastases are valuable translational platforms for the development of personalized targeted therapy.
    Authors: Lee H, Lee J, Lee S, Cho H, Song H, Jeong D, Seo Y, Shin S, Joung J, Kwon Y, Choi Y, Park W, Lee H, Seol H, Shim Y, Joo K, Nam D
    Clin Cancer Res, 2014-12-30;21(5):1172-82.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  147. IGFBP-4 and -5 are expressed in first-trimester villi and differentially regulate the migration of HTR-8/SVneo cells.
    Authors: Crosley, Erin J, Dunk, Caroline, Beristain, Alexande, Christians, Julian K
    Reprod Biol Endocrinol, 2014-12-04;12(0):123.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  148. Specific activation of insulin-like growth factor-1 receptor by ginsenoside Rg5promotes angiogenesis and vasorelaxation.
    Authors: Cho Y, Hur S, Kim J, Kim J, Lee D, Choe J, Won M, Ha K, Jeoung D, Han S, Ryoo S, Lee H, Min J, Kwon Y, Kim D, Kim Y
    J Biol Chem, 2014-11-12;290(1):467-77.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  149. Insulin-like growth factor-I induces epithelial to mesenchymal transition via GSK-3beta and ZEB2 in the BGC-823 gastric cancer cell line.
    Authors: Li H, Xu L, Zhao L, Ma Y, Zhu Z, Liu Y, Qu X
    Oncol Lett, 2014-11-07;9(1):143-148.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  150. Restoring Akt1 activity in outgrowth endothelial cells from South Asian men rescues vascular reparative potential.
    Authors: Cubbon R, Yuldasheva N, Viswambharan H, Mercer B, Baliga V, Stephen S, Askham J, Sukumar P, Skromna A, Mughal R, Walker A, Bruns A, Bailey M, Galloway S, Imrie H, Gage M, Rakobowchuk M, Li J, Porter K, Ponnambalam S, Wheatcroft S, Beech D, Kearney M
    Stem Cells, 2014-10-01;32(10):2714-23.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  151. Phosphoinositide protein kinase PDPK1 is a crucial cell signaling mediator in multiple myeloma.
    Authors: Chinen Y, Kuroda J, Shimura Y, Nagoshi H, Kiyota M, Yamamoto-Sugitani M, Mizutani S, Sakamoto N, Ri M, Kawata E, Kobayashi T, Matsumoto Y, Horiike S, Iida S, Taniwaki M
    Cancer Res, 2014-09-30;74(24):7418-29.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  152. Human IGF1 regulates midgut oxidative stress and epithelial homeostasis to balance lifespan and Plasmodium falciparum resistance in Anopheles stephensi.
    Authors: Drexler A, Pietri J, Pakpour N, Hauck E, Wang B, Glennon E, Georgis M, Riehle M, Luckhart S
    PLoS Pathog, 2014-06-26;10(6):e1004231.
    Species: Insect
    Sample Types: In Vivo
    Applications: In Vivo
  153. Selective and potent Akt inhibition triggers anti-myeloma activities and enhances fatal endoplasmic reticulum stress induced by proteasome inhibition.
    Authors: Mimura N, Hideshima T, Shimomura T, Suzuki R, Ohguchi H, Rizq O, Kikuchi S, Yoshida Y, Cottini F, Jakubikova J, Cirstea D, Gorgun G, Minami J, Tai Y, Richardson P, Utsugi T, Iwama A, Anderson K
    Cancer Res, 2014-06-16;74(16):4458-69.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  154. Ubiquitin ligase Cbl-b represses IGF-I-induced epithelial mesenchymal transition via ZEB2 and microRNA-200c regulation in gastric cancer cells.
    Authors: Li H, Xu L, Li C, Zhao L, Ma Y, Zheng H, Li Z, Zhang Y, Wang R, Liu Y, Qu X
    Mol Cancer, 2014-06-02;13(0):136.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  155. Co-targeting the IGF system and HIF-1 inhibits migration and invasion by (triple-negative) breast cancer cells.
    Authors: Mancini M, Gariboldi M, Taiana E, Bonzi M, Craparotta I, Pagin M, Monti E
    Br J Cancer, 2014-05-22;110(12):2865-73.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  156. MicroRNA-133a suppresses multiple oncogenic membrane receptors and cell invasion in non-small cell lung carcinoma.
    Authors: Wang, Lu-Kai, Hsiao, Tzu-Hung, Hong, Tse-Ming, Chen, Hsuan-Yu, Kao, Shih-Han, Wang, Wen-Lung, Yu, Sung-Lia, Lin, Ching-We, Yang, Pan-Chyr
    PLoS ONE, 2014-05-09;9(5):e96765.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  157. CEP290 gene transfer rescues Leber congenital amaurosis cellular phenotype.
    Authors: Burnight E, Wiley L, Drack A, Braun T, Anfinson K, Kaalberg E, Halder J, Affatigato L, Mullins R, Stone E, Tucker B
    Gene Ther, 2014-05-08;21(7):662-72.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  158. Minimally invasive approach to the repair of injured skeletal muscle with a shape-memory scaffold.
    Authors: Wang, Lin, Cao, Lan, Shansky, Janet, Wang, Zheng, Mooney, David, Vandenburgh, Herman
    Mol Ther, 2014-04-28;22(8):1441-9.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  159. Involvement of ER stress in dysmyelination of Pelizaeus-Merzbacher Disease with PLP1 missense mutations shown by iPSC-derived oligodendrocytes.
    Authors: Numasawa-Kuroiwa Y, Okada Y, Shibata S, Kishi N, Akamatsu W, Shoji M, Nakanishi A, Oyama M, Osaka H, Inoue K, Takahashi K, Yamanaka S, Kosaki K, Takahashi T, Okano H
    Stem Cell Reports, 2014-04-24;2(5):648-61.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  160. Circumvention of Mcl-1-dependent drug resistance by simultaneous Chk1 and MEK1/2 inhibition in human multiple myeloma cells.
    Authors: Pei X, Dai Y, Felthousen J, Chen S, Takabatake Y, Zhou L, Youssefian L, Sanderson M, Bodie W, Kramer L, Orlowski R, Grant S
    PLoS ONE, 2014-03-04;9(3):e89064.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  161. The multifunctional growth factor midkine promotes proliferation and migration in pancreatic cancer.
    Authors: Rawnaq T, Dietrich L, Wolters-Eisfeld G, Uzunoglu F, Vashist Y, Bachmann K, Simon R, Izbicki J, Bockhorn M, Gungor C
    Mol Cancer Res, 2014-02-24;12(5):670-80.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  162. The combined hyperlipidemia caused by impaired Wnt-LRP6 signaling is reversed by Wnt3a rescue.
    Authors: Go G, Srivastava R, Hernandez-Ono A, Gang G, Smith S, Booth C, Ginsberg H, Mani A
    Cell Metab, 2014-02-04;19(2):209-20.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  163. Insulin-like growth factor 1 receptor is a prognostic factor in classical Hodgkin lymphoma.
    Authors: Liang Z, Diepstra A, Xu C, van Imhoff G, Plattel W, Van Den Berg A, Visser L
    PLoS ONE, 2014-01-28;9(1):e87474.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  164. Human cytomegalovirus infection of human embryonic stem cell-derived primitive neural stem cells is restricted at several steps but leads to the persistence of viral DNA.
    Authors: Belzile, Jean-Phi, Stark, Thomas J, Yeo, Gene W, Spector, Deborah
    J Virol, 2014-01-22;88(8):4021-39.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  165. Epigallocatechin-3-gallate inhibits cell growth, induces apoptosis and causes S phase arrest in hepatocellular carcinoma by suppressing the AKT pathway.
    Authors: Shen X, Zhang Y, Feng Y, Zhang L, Li J, Xie Y, Luo X
    Int J Oncol, 2014-01-08;44(3):791-6.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  166. The adherens junction protein afadin is an AKT substrate that regulates breast cancer cell migration.
    Authors: Elloul, Sivan, Kedrin, Dmitriy, Knoblauch, Nicholas, Beck, Andrew H, Toker, Alex
    Mol Cancer Res, 2013-11-22;12(3):464-76.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  167. Expansion and conversion of human pancreatic ductal cells into insulin-secreting endocrine cells.
    Authors: Lee J, Sugiyama T, Liu Y, Wang J, Gu X, Lei J, Markmann J, Miyazaki S, Miyazaki J, Szot G, Bottino R, Kim S
    Elife, 2013-11-19;2(0):e00940.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  168. Role of IGF-1 pathway in lung fibroblast activation.
    Authors: Hung C, Rohani M, Lee S, Chen P, Schnapp L
    Respir Res, 2013-10-08;14(0):102.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  169. Patient-specific iPSC-derived photoreceptor precursor cells as a means to investigate retinitis pigmentosa.
    Authors: Tucker, Budd A, Mullins, Robert F, Streb, Luan M, Anfinson, Kristin, Eyestone, Mari E, Kaalberg, Emily, Riker, Megan J, Drack, Arlene V, Braun, Terry A, Stone, Edwin M
    Elife, 2013-08-27;2(0):e00824.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  170. Selective tyrosine kinase inhibition of insulin-like growth factor-1 receptor inhibits human and mouse breast cancer-induced bone cell activity, bone remodeling, and osteolysis.
    Authors: Logan J, Sophocleous A, Marino S, Muir M, Brunton V, Idris A
    J Bone Miner Res, 2013-05-01;28(5):1229-42.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  171. Medial ganglionic eminence-like cells derived from human embryonic stem cells correct learning and memory deficits.
    Authors: Liu Y, Weick J, Liu H, Krencik R, Zhang X, Ma L, Zhou G, Ayala M, Zhang S
    Nat Biotechnol, 2013-04-21;31(5):440-7.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  172. Rapid and efficient directed differentiation of human pluripotent stem cells into retinal pigmented epithelium.
    Authors: Buchholz, David E, Pennington, Britney, Croze, Roxanne, Hinman, Cassidy, Coffey, Peter J, Clegg, Dennis O
    Stem Cells Transl Med, 2013-04-18;2(5):384-93.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  173. Protein distribution during human erythroblast enucleation in vitro.
    Authors: Bell A, Satchwell T, Heesom K, Hawley B, Kupzig S, Hazell M, Mushens R, Herman A, Toye A
    PLoS ONE, 2013-04-02;8(4):e60300.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  174. Targeting both IGF-1R and mTOR synergistically inhibits growth of renal cell carcinoma in vitro.
    Authors: Cardillo T, Trisal P, Arrojo R, Goldenberg D, Chang C
    BMC Cancer, 2013-04-01;13(0):170.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  175. Insulin signaling via Akt2 switches plakophilin 1 function from stabilizing cell adhesion to promoting cell proliferation.
    Authors: Wolf A, Rietscher K, Glass M, Huttelmaier S, Schutkowski M, Ihling C, Sinz A, Wingenfeld A, Mun A, Hatzfeld M
    J Cell Sci, 2013-02-26;126(0):1832-44.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  176. Use of a synthetic xeno-free culture substrate for induced pluripotent stem cell induction and retinal differentiation.
    Authors: Tucker B, Anfinson K, Mullins R, Stone E, Young M
    Stem Cells Transl Med, 2012-12-27;2(1):16-24.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  177. Intrapatient variations in type 1 diabetes-specific iPS cell differentiation into insulin-producing cells.
    Authors: Thatava T, Kudva Y, Edukulla R, Squillace K, De Lamo J, Khan Y, Sakuma T, Ohmine S, Terzic A, Ikeda Y
    Mol Ther, 2012-11-27;21(1):228-39.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  178. The hedgehog system in ovarian follicles of cattle selected for twin ovulations and births: evidence of a link between the IGF and hedgehog systems.
    Authors: Aad, Pauline, Echternkamp, Sherrill, Sypherd, David D, Schreiber, Nicole B, Spicer, Leon J
    Biol Reprod, 2012-10-04;87(4):79.
    Species: Bovine
    Sample Types: Whole Cells
    Applications: Bioassay
  179. The reactivity, distribution and abundance of Non-astrocytic Inner Retinal Glial (NIRG) cells are regulated by microglia, acute damage, and IGF1.
    Authors: Zelinka C, Scott M, Volkov L, Fischer A
    PLoS ONE, 2012-09-04;7(9):e44477.
    Species: Chicken
    Sample Types: In Vivo
    Applications: In Vivo
  180. Fibroblast growth factor-2 maintains a niche-dependent population of self-renewing highly potent non-adherent mesenchymal progenitors through FGFR2c.
    Authors: Di Maggio N, Mehrkens A, Papadimitropoulos A, Schaeren S, Heberer M, Banfi A, Martin I
    Stem Cells, 2012-07-01;30(7):1455-64.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  181. Generation of glucose-responsive, insulin-producing cells from human umbilical cord blood-derived mesenchymal stem cells.
    Authors: Prabakar K, Dominguez-Bendala J, Molano R, Pileggi A, Villate S, Ricordi C, Inverardi L
    Cell Transplant, 2011-12-21;21(6):1321-39.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  182. IGFBP7 participates in the reciprocal interaction between acute lymphoblastic leukemia and BM stromal cells and in leukemia resistance to asparaginase.
    Authors: Laranjeira AB, de Vasconcellos JF, Sodek L, Spago MC, Fornazim MC, Tone LG, Brandalise SR, Nowill AE, Yunes JA
    Leukemia, 2011-10-18;26(5):1001-11.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  183. Decorin antagonizes IGF receptor I (IGF-IR) function by interfering with IGF-IR activity and attenuating downstream signaling.
    Authors: Iozzo RV, Buraschi S, Genua M
    J. Biol. Chem., 2011-08-12;286(40):34712-21.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  184. IGF-1 increases invasive potential of MCF 7 breast cancer cells and induces activation of latent TGF-beta1 resulting in epithelial to mesenchymal transition.
    Authors: Walsh L, Damjanovski S
    Cell Commun Signal, 2011-05-02;9(1):10.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  185. A novel type of glial cell in the retina is stimulated by insulin-like growth factor 1 and may exacerbate damage to neurons and Muller glia.
    Authors: Fischer AJ, Scott MA, Zelinka C, Sherwood P
    Glia, 2010-04-15;58(6):633-49.
    Species: Chicken
    Sample Types: In Vivo
    Applications: In Vivo
  186. Molecular pharmacology and antitumor activity of PHT-427, a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor.
    Authors: Meuillet EJ, Zuohe S, Lemos R, Ihle N, Kingston J, Watkins R, Moses SA, Zhang S, Du-Cuny L, Herbst R, Jacoby JJ, Zhou LL, Ahad AM, Mash EA, Kirkpatrick DL, Powis G
    Mol. Cancer Ther., 2010-03-02;9(3):706-17.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  187. Growth hormone promotes lymphangiogenesis.
    Authors: Banziger-Tobler NE, Halin C, Kajiya K, Detmar M
    Am. J. Pathol., 2008-06-26;173(2):586-97.
    Applications: Western Blot
  188. High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells.
    Authors: Desbordes SC, Placantonakis DG, Ciro A, Socci ND, Lee G, Djaballah H, Studer L
    Cell Stem Cell, 2008-06-05;2(6):602-12.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  189. Insulin-like growth factor-I receptor blockade by a specific tyrosine kinase inhibitor for human gastrointestinal carcinomas.
    Authors: Piao W, Wang Y, Adachi Y, Yamamoto H, Li R, Imsumran A, Li H, Maehata T, Ii M, Arimura Y, Lee CT, Shinomura Y, Carbone DP, Imai K
    Mol. Cancer Ther., 2008-06-01;7(6):1483-93.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  190. Development and validation of sandwich ELISA microarrays with minimal assay interference.
    Authors: Gonzalez RM, Seurynck-Servoss SL, Crowley SA
    J. Proteome Res., 2008-04-19;7(6):2406-14.
    Applications: ELISA (Standard)
  191. Regulation of bone morphogenetic protein signalling in human pulmonary vascular development.
    Authors: Southwood M, Jeffery TK, Yang X, Upton PD, Hall SM, Atkinson C, Haworth SG, Stewart S, Reynolds PN, Long L, Trembath RC, Morrell NW
    J. Pathol., 2008-01-01;214(1):85-95.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  192. GRP94 is essential for mesoderm induction and muscle development because it regulates insulin-like growth factor secretion.
    Authors: Wanderling S, Simen BB, Ostrovsky O, Ahmed NT, Vogen SM, Gidalevitz T, Argon Y
    Mol. Biol. Cell, 2007-07-18;18(10):3764-75.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  193. Insulin-like growth factor (IGF) 2 stimulates steroidogenesis and mitosis of bovine granulosa cells through the IGF1 receptor: role of follicle-stimulating hormone and IGF2 receptor.
    Authors: Spicer LJ, Aad PY
    Biol. Reprod., 2007-03-14;77(1):18-27.
    Species: Bovine
    Sample Types: Whole Cells
    Applications: Bioassay
  194. The effect of insulin-like growth factor-I on hepatocyte apoptosis after bile duct ligation in rat.
    Authors: Sheen-Chen SM, Ho HT, Chia-Pei L, Hung KS, Eng HL
    Dig. Dis. Sci., 2006-11-11;51(12):2220-4.
    Species: Rat
    Sample Types: In Vivo
    Applications: In Vivo
  195. Pretreatment of adult bone marrow mesenchymal stem cells with cardiomyogenic growth factors and repair of the chronically infarcted myocardium.
    Authors: Bartunek J, Croissant JD, Wijns W, Gofflot S, de Lavareille A, Vanderheyden M, Kaluzhny Y, Mazouz N, Willemsen P, Penicka M, Mathieu M, Homsy C, De Bruyne B, McEntee K, Lee IW, Heyndrickx GR
    Am. J. Physiol. Heart Circ. Physiol., 2006-10-20;292(2):H1095-104.
    Species: Canine, Human
    Sample Types: Whole Cells
    Applications: Bioassay
  196. Insulin-like growth factor binding protein-4 (IGFBP-4) is a novel anti-angiogenic and anti-tumorigenic mediator secreted by dibutyryl cyclic AMP (dB-cAMP)-differentiated glioblastoma cells.
    Authors: Moreno MJ, Ball M, Andrade MF, McDermid A, Stanimirovic DB
    Glia, 2006-06-01;53(8):845-57.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  197. Increased extraocular muscle strength with direct injection of insulin-like growth factor-I.
    Authors: Anderson BC, Christiansen SP, Grandt S, Grange RW, McLoon LK
    Invest. Ophthalmol. Vis. Sci., 2006-06-01;47(6):2461-7.
    Species: Rabbit
    Sample Types: In Vivo
    Applications: In Vivo
  198. Transforming growth factor-alpha: a major human serum factor that promotes human keratinocyte migration.
    Authors: Li Y, Fan J, Chen M, Li W, Woodley DT
    J. Invest. Dermatol., 2006-05-11;126(9):2096-105.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  199. Growth differentiation factor-9 has divergent effects on proliferation and steroidogenesis of bovine granulosa cells.
    Authors: Spicer LJ, Aad PY, Allen D, Mazerbourg S, Hsueh AJ
    J. Endocrinol., 2006-05-01;189(2):329-39.
    Species: Bovine
    Sample Types: Whole Cells
    Applications: Bioassay
  200. Myelin formation during development of the CNS is delayed in matrix metalloproteinase-9 and -12 null mice.
    Authors: Larsen PH, DaSilva AG, Conant K, Yong VW
    J. Neurosci., 2006-02-22;26(8):2207-14.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  201. Growth hormone-induced stimulation of multilineage human hematopoiesis.
    Authors: Hanley MB, Napolitano LA, McCune JM
    Stem Cells, 2005-06-13;23(8):1170-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  202. Insulin growth factor-1 protects against excitotoxicity in the rat striatum.
    Authors: Escartin C, Boyer F, Bemelmans AP, Hantraye P, Brouillet E
    Neuroreport, 2004-10-05;15(14):2251-4.
    Species: Rat
    Sample Types: In Vivo
    Applications: In Vivo
  203. Local delivery of growth factors from coated titanium plates increases osteotomy healing in rats.
    Authors: Wildemann B, Bamdad P, Holmer Ch, Haas NP, Raschke M, Schmidmaier G
    Bone, 2004-05-01;34(5):862-8.
    Species: Rat
    Sample Types: In Vivo
    Applications: In Vivo
  204. Quantification, localization, and expression of IGF-I and TGF-beta1 during growth factor-stimulated fracture healing.
    Authors: Brenner N, Huning M, Stange R
    Calcif. Tissue Int., 2004-04-01;74(4):388-97.
    Species: Rat
    Sample Types: In Vivo
    Applications: In Vivo
  205. Improvement of the developmental capacity of oocytes from prepubertal cattle by intraovarian insulin-like growth factor-I application.
    Authors: Oropeza A, Wrenzycki C, Herrmann D, Hadeler KG, Niemann H
    Biol. Reprod., 2004-02-06;70(6):1634-43.
    Species: Bovine
    Sample Types: In Vivo
    Applications: In Vivo
  206. The effects of in ovo rhIGF-I administration on expression of the growth hormone secretagogue receptor (GHSR) during chicken embryonic development.
    Authors: Gahr SA, Kocamis H, Richter JJ, Killefer J
    Growth Dev Aging, 2004-01-01;68(1):3-10.
    Species: Chicken
    Sample Types: In Vivo
    Applications: In Vivo
  207. Chondrocyte response to growth factors is modulated by p38 mitogen-activated protein kinase inhibition.
    Authors: Studer RK, Bergman R, Stubbs T, Decker K
    Arthritis Res. Ther., 2003-11-07;6(1):R56-R64.
    Species: Rabbit
    Sample Types: Whole Cells
    Applications: Bioassay
  208. Detection of nitrotyrosine in aging and osteoarthritic cartilage: Correlation of oxidative damage with the presence of interleukin-1beta and with chondrocyte resistance to insulin-like growth factor 1.
    Authors: Loeser RF, Carlson CS, Del Carlo M, Cole A
    Arthritis Rheum., 2002-09-01;46(9):2349-57.
    Species: Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)
    Sample Types: Whole Cells
    Applications: Bioassay
  209. Activation of NF-kappaB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma cells: therapeutic implications.
    Authors: Mitsiades CS, Mitsiades N, Poulaki V, Schlossman R, Akiyama M, Chauhan D, Hideshima T, Treon SP, Munshi NC, Richardson PG, Anderson KC
    Oncogene, 2002-08-22;21(37):5673-83.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  210. Quantitative assessment of the integrity of the blood-retinal barrier in mice.
    Authors: Derevjanik NL, Vinores SA, Xiao WH, Mori K, Turon T, Hudish T, Dong S, Campochiaro PA
    Invest. Ophthalmol. Vis. Sci., 2002-07-01;43(7):2462-7.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  211. Reduction in the chondrocyte response to insulin-like growth factor 1 in aging and osteoarthritis: studies in a non-human primate model of naturally occurring disease.
    Authors: Loeser RF, 2018, Shanker G, Carlson CS, Gardin JF, Shelton BJ, Sonntag WE
    e0194453, 2000-09-01;43(9):2110-20.
    Species: Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)
    Sample Types: Whole Cells
    Applications: Bioassay
  212. Immediate early gene expression in dog thyrocytes in response to growth, proliferation, and differentiation stimuli.
    Authors: Deleu S, Pirson I, Clermont F, Nakamura T, Dumont JE, Maenhaut C
    J. Cell. Physiol., 1999-11-01;181(2):342-54.
    Species: Canine
    Sample Types: Whole Cells
    Applications: Bioassay

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Reviews for Recombinant Human IGF-I/IGF-1 Protein, CF

Average Rating: 4.6 (Based on 8 Reviews)

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Recombinant Human IGF-I/IGF-1 Protein, CF
By Anonymous on 07/23/2021
Application: CellProlif
Recombinant Human IGF-I/IGF-1 Protein, CF
By Anonymous on 05/14/2021
Application: Immunoassay Standard
Immunoassay Standard Recombinant Human IGF-I/IGF-1 Protein, CF 291-G1
Recombinant Human IGF-I/IGF-1 Protein, CF
By Anonymous on 02/28/2021
Application: CellProlif
Recombinant Human IGF-I/IGF-1 Protein, CF
By Anonymous on 01/09/2020
Application: Stem/Immune cell maintenance or differentiation
Reason for Rating: Performed very well in differentiating of human iPS cells into oligodendrocytes progenitor cells
Stem/Immune cell maintenance or differentiation Recombinant Human IGF-I/IGF-1 Protein, CF 291-G1
Recombinant Human IGF-I/IGF-1 Protein, CF
By Anonymous on 10/09/2019
Application: CellProlif
Cell Proliferation Recombinant Human IGF-I/IGF-1 Protein, CF 291-G1
Recombinant Human IGF-I/IGF-1 Protein, CF
By Anonymous on 07/26/2018
Application: Cell migration/motility
Recombinant Human IGF-I Protein, CF
By Balaji Mahender on 02/26/2018
Application: Immunoassay Standard
Recombinant Human IGF-I Protein, CF
By Michelle Chen on 05/10/2017
Application: CellProlif