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TTNPB

Catalog #: 0761
7 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
0761/10
0761/50
TTNPB | CAS No. 71441-28-6 | Retinoic Acid Receptor Agonists
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Description: Retinoic acid analog; RAR agonist
Alternative Names: Ro 13-7410

Chemical Name: 4-[(E)-2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl]benzoic acid

Purity: ≥98%

Product Details
Citations (7)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

TTNPB is an extremely potent analog of retinoic acid, selective for the retinoic acid receptor (RAR) subtype. Enhances reprogramming efficiency in chemically induced pluripotent stem cells (CiPSCs).

Technical Data

M.Wt:
348.48
Formula:
C24H28O2
Solubility:
Soluble to 10 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at -20°C
CAS No:
71441-28-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Retinoid X receptor-selective ligands produce malformations in Xenopus embryos.
    Minucci et al.
    Proc.Natl.Acad.Sci.U.S.A., 1996;93:1803
  2. Arotinoids, a new class of highly active retinoids.
    Loeliger et al.
    Eur.J.Med.Chem.-Chim.Ther., 1980;15:9
  3. Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds.
    Hou et al.
    Science, 2013;341:651

Product Datasheets

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Citations for TTNPB

The citations listed below are publications that use Tocris products. Selected citations for TTNPB include:

7 Citations: Showing 1 - 7

  1. Interplay of Protein Disorder in Retinoic Acid Receptor Heterodimer and Its Corepressor Regulates Gene Expression.
    Authors: Cordeiro Et al.
    Structure  2019;
  2. Retinoic acid inhibits white adipogenesis by disrupting GADD45A-mediated Zfp423 DNA demethylation.
    Authors: Wang Et al.
    J Mol Cell Biol  2017;9:338
  3. ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion
    Authors: Chronopoulos Et al.
    Nature Communications  2016;7:12630
  4. The lymph node as a new site for kidney organogenesis.
    Authors: Francipane and Lagasse
    Stem Cells Transl Med  2015;4:295
  5. Small Molecules Efficiently Reprogram Human Astroglial Cells into Functional Neurons.
    Authors: Zhang Et al.
    Cell Stem Cell  2015;17:735
  6. Retinoic acid regulation by CYP26 in vertebrate lens regeneration.
    Authors: Thomas and Henry
    Br J Pharmacol  2014;386:291
  7. A comparison of the roles of peroxisome proliferator-activated receptor and retinoic acid receptor on CYP26 regulation.
    Authors: Tay Et al.
    Mol Pharmacol  2010;77:218

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