Home / Voltage-gated Potassium Channel Blockers / (-)-[3R,4S]-Chromanol 293B

(-)-[3R,4S]-Chromanol 293B

Catalog #: 1475
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
1475/10
1475/50
(-)-[3R,4S]-Chromanol 293B | CAS No. 163163-24-4 | Voltage-gated Potassium Channel Blockers
1 Image
Description: IKs blocker. Enantiomer of Chromanol 293B (Cat. No. 1412)

Chemical Name: N-[(3R,4S)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methylethanesulfonamide

Purity: ≥99%

Product Details
Citations (3)
Supplemental Products
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

(-)-[3R,4S]-Chromanol 293B is a enantiomer that selectively inhibits the slow component of delayed rectifier K+ current (IKs). Block is use-dependent and 7-fold more potent than the (+)-(3S,4R) enantiomer (IC50 values are 1.36 and 9.6 μM respectively). Has negligible inhibitory action at KV11.1 (hERG) channels (IC50 > 30 μM).

Racemate also available.

Technical Data

M.Wt:
324.39
Formula:
C15H20N2O4S
Solubility:
Soluble to 100 mM in ethanol with gentle warming and to 100 mM in DMSO with gentle warming
Purity:
≥99%
Storage:
Store at RT
CAS No:
163163-24-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

Product Datasheets

COA view current batch
Or select another batch:
View Batch
SDS
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for (-)-[3R,4S]-Chromanol 293B

The citations listed below are publications that use Tocris products. Selected citations for (-)-[3R,4S]-Chromanol 293B include:

3 Citations: Showing 1 - 3

  1. Sigma non-opioid receptor 1 is a potential therapeutic target for long QT syndrome.
    Authors: Song Et al.
    Nat.Card.Res.  2022;1:142
  2. The KCNQ1-KCNE2 K+ channel is required for adequate thyroid I- uptake.
    Authors: Purtell Et al.
    Neuropharmacology  2012;26:3252
  3. High purity human-induced pluripotent stem cell-derived cardiomyocytes: electrophysiological properties of action potentials and ionic currents.
    Authors: Ma Et al.
    FASEB J  2011;301:H2006

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for (-)-[3R,4S]-Chromanol 293B

There are currently no reviews for this product. Be the first to review (-)-[3R,4S]-Chromanol 293B and earn rewards!

Have you used (-)-[3R,4S]-Chromanol 293B?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.