Home / Voltage-gated Potassium Channel Blockers / Chromanol 293B

Chromanol 293B

Catalog #: 1412
5 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
1412/10
1412/50
Chromanol 293B | CAS No. 163163-23-3 | Voltage-gated Potassium Channel Blockers
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Description: IKs blocker. Also blocks ICFTR

Chemical Name: trans-N-[6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methyl-ethanesulfonamide

Purity: ≥99%

Product Details
Citations (5)
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Biological Activity

Chromanol 293B is a blocker of the slow delayed rectifier K+ current (IKs) (IC50 = 1-10 μM). Also blocks the CFTR chloride current (ICFTR) (IC50 = 19 μM).

Enantiomer also available.

Technical Data

M.Wt:
324.39
Formula:
C15H20N2O4S
Solubility:
Soluble to 20 mM in ethanol and to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
163163-23-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

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Citations for Chromanol 293B

The citations listed below are publications that use Tocris products. Selected citations for Chromanol 293B include:

5 Citations: Showing 1 - 5

  1. Involvement of butyrate in electrogenic K+ secretion in rat rectal colon.
    Authors: Inagaki Et al.
    Pflugers Arch  2019;471:313
  2. Apamin does not inhibit human cardiac Na+ current, L-type Ca2+ current or other major K+ currents.
    Authors: Yu Et al.
    J Cell Mol Med  2014;9:e96691
  3. Renal defects in KCNE1 knockout mice are mimicked by chromanol 293B in vivo: identification of a KCNE1-regulated K+ conductance in the proximal tubule.
    Authors: Neal Et al.
    J Physiol  2011;589:3595
  4. The contribution of Kv7 channels to pregnant mouse and human myometrial contractility.
    Authors: McCallum Et al.
    Mol Pain  2011;15:577
  5. KCNE3 truncation mutants reveal a bipartite modulation of KCNQ1 K+ channels.
    Authors: Gage and Kobertz
    J Gen Physiol  2004;124:759

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