CELT-211
Purity: ≥95%
Biological Activity
CELT-211 is a potent and selective fluorescent h5HT2B serotonin receptor ligand. It shows full selectivity for h5HT2B over h5HT2A, h5HT2C (Ki values is 56.3 nM for h5HT2B receptors in radioligand binding assay). Excitation and emission maxima (λ) are 589 and 616 nm, respectively. Wavelengths are compatible with use as an acceptor dye in TR-FRET assays, together with the CoraFluor™ 1 (Cat. No. 7920) TR-FRET donor.Add 82 μL of assay buffer containing 1% of DMSO to obtain a 100 μM stock solution, and use 250 nM as a working concentration.
Scientific Data
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Application of CELT-211 in CHO cells expressing the human 5HT2BR. CHO cells expressing the human 5HT2BR labelled with CELT-211 (pink) at 56 nM and Hoechst 33342 (blue) (catalog # 5117) without (A) or with (B) 5-HT (50 µM) preincubation.
Optical Data for CELT-211
| λabs | 589 nm |
|---|---|
| λem | 616 nm |
| Application | Time-resolved fluorescence energy transfer (TR-FRET) |
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Use our spectra viewer to interactively plan your experiments, assessing multiplexing options. View the excitation and emission spectra for our fluorescent dye range and other commonly used dyes.
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Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
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