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CoraFluor™ 1, amine reactive

Catalog #: 7920 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7920/20U
CoraFluor™ 1, amine reactive | Fluorescent Probes
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Description: Terbium cryptate FRET donor for TR-FRET assay development; amine reactive for conjugation
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Biological Activity

CoraFluor™ 1, amine reactive is a terbium-based time-resolved Förster resonance energy transfer (TR-FRET) donor for TR-FRET assay development, such as target engagement and ternary complex assays. This product is designed with a PFP ester for reactivity with primary amines, making it suitable for labeling biomolecules, including antibodies, nanobodies, proteins and peptides. It is exceptionally bright, providing unmatched assay sensitivity and stability in biological media over other commercially available TR-FRET donors. CoraFluor™ 1 amine reactive is compatible with common acceptor dyes such as FAM, TMR and Cyanine 5, SE (Cat. No. 5436), enabling seamless assay integration in high throughput screening applications.

Please refer to the protocol for further information on conjugation.

CoraFluor™ is a trademark of Bio-Techne Corp.

Scientific Data

N/A CoraFluor™ 1 stability profile View Larger

CoraFluor™ 1 stability profile. Stability profiling of CoraFluor™ 1 and a commercially available TR-FRET donor (5 nM) after 7 days of exposure to 50 mM PBS, acetic acid (pH 3), sodium acetate (pH 5), MES (pH 6) or Tris buffer (pH 7.5) supplemented with various additives (DTPA, Ca2+, Mg2+, DTT, TCEP = 1 mM; Mn2+, Cu2+ = 0.5 mM).

Binding Activity View Larger

CoraFluor™ TR-FRET target engagement assay High throughput TR-FRET target engagement assay profiling BRD4 inhibitors and Degraders on endogenous BRD4 using a single detection mix consisting of a primary BRD4 antibody, a CoraFluor™ 1 labeled VHH secondary antibody, and a fluorescent JQ1-based tracer (JQ1-FITC Catalog #7722).

Technical Data

M.Wt:
1485.25
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes only under agreement from Massachusetts General Hospital. US patent 2022/0025254

Product Datasheets

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Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.