Human MAG/Siglec-4a (NP_002352) VersaClone cDNA

Catalog #: RDC1566 Datasheet / COA / SDS

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RDC1566

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Human MAG/Siglec-4a (NP_002352) VersaClone cDNA Summary

Specifications

Source

N/A

Shipping Conditions

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Species

Human

Product Datasheets

Product Datasheet

COA

SDS

Background: MAG/Siglec-4a

MAG (Myelin-Associated Glycoprotein), also known as Siglec-4a, is a transmembrane lectin that preferentially binds to alpha-2,3-linked sialic acid terminal carbohydrates on cell surface molecules. It is expressed by myelinating oligodendrocytes and Schwann cells and plays an important role in axon-myelin stability. MAG also regulates axon structure at nodes of Ranvier, inhibits neurite outgrowth, and protects neurons from excitotoxicity. It interacts with the gangliosides GD1a and GT1b, the Nogo receptors NgR1 and NgR2/NgRH1, Integrin beta 1/CD29, and PIR-B. Proteolytic cleavage releases a soluble form that is released from myelin in large quantities.

Long Name

Myelin-associated Glycoprotein

Entrez Gene IDs

4099 (Human); 17136 (Mouse); 29409 (Rat)

Alternate Names

GMAsialic acid binding Ig-like lectin 4A; MAG; myelin associated glycoprotein; myelin-associated glycoprotein; sialic acid-binding immunoglobulin-like lectin 4A; Siglec4a; Siglec-4a; S-MAG