Human/Mouse/Rat GAPDH Antibody Summary
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
Detection of Human, Mouse, and Rat GAPDH/G3PDH by Western Blot. Western blot shows lysates of U2OS human osteosarcoma cell line, A20 mouse B cell lymphoma cell line, and L6 rat myoblast cell line. PVDF membrane was probed with 0.1 µg/mL Rabbit Anti-Human/Mouse/Rat GAPDH Polyclonal Antibody (Catalog # 2275-PC) followed by HRP-conjugated Anti-Rabbit IgG Secondary Antibody (Catalog # HAF008). A specific band was detected for GAPDH at approximately 36 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.
Detection of Human, Mouse and Rat GAPDH by Simple WesternTM. Simple Western lane view shows lysates of Jurkat human acute T cell leukemia cell line, C2C12 mouse myoblast cell line, and C6 rat glioma cell line, loaded at 0.2 mg/mL. A specific band was detected for GAPDH at approximately 43 kDa (as indicated) using 1 µg/mL of Rabbit Anti-Human/Mouse/Rat GAPDH Antigen Affinity-purified Polyclonal Antibody (Catalog # 2275-PC-100). This experiment was conducted under reducing conditions and using the 12-230 kDa separation system.
Reconstitution Calculator
Preparation and Storage
Background: GAPDH
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a 36‑40 kDa member of the GAPDH family of enzymes. It is a widely expressed heterotetramer that is found in both the nucleus and cytoplasm. Although GAPDH was initially identified as a glycolytic enzyme that converted G3P into 1,3 diphosphoglycerate, it is now recognized to participate in no less than endocytosis, membrane fusion, vesicular secretory transport, DNA replication and repair, and apoptosis. Human GAPDH is 335 amino acids (aa) in length and contains two NAD binding sites (Asp35 and Asn316) with a catalytic region between aa 151‑155. GAPDH contains more than 19 posttranslational modifications, including methylation, deamidation and phosphorylation. One splice variant shows a 10 aa substitution for aa 319‑335. Over amino acid 1‑150, human GAPDH shares 92% aa identity with mouse GAPDH.
Product Datasheets
Citations for Human/Mouse/Rat GAPDH Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 10
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Novel Bruton's tyrosine kinase inhibitor TAS5315 suppresses the progression of inflammation and joint destruction in rodent collagen-induced arthritis
Authors: D Akasaka, S Iguchi, R Kaneko, Y Yoshiga, D Kajiwara, Y Nakachi, N Noma, K Tanaka, A Shimizu, F Hosoi
PLoS ONE, 2023-02-23;18(2):e0282117.
Species: Human
Sample Types: Whole Cells
Applications: Positive Control -
Selective Eradication of Colon Cancer Cells Harboring PI3K and/or MAPK Pathway Mutations in 3D Culture by Combined PI3K/AKT/mTOR Pathway and MEK Inhibition
Authors: VS Atanasova, A Riedl, M Strobl, J Flandorfer, D Unterleuth, C Weindorfer, P Neuhold, S Stang, M Hengstschl, M Bergmann, H Dolznig
International Journal of Molecular Sciences, 2023-01-14;24(2):.
Species: Human
Sample Types: Cell culture supernate
Applications: Western Blot -
Vitamin C enhances NF-kappaB-driven epigenomic reprogramming and boosts the immunogenic properties of dendritic cells
Authors: O Morante-Pa, G Godoy-Tena, J Calafell-S, L Ciudad, EM Martínez-C, JL Sardina, E Ballestar
Nucleic Acids Research, 2022-10-28;50(19):10981-10994.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Nanomedicine-Based Gene Delivery for a Truncated Tumor Suppressor RB94 Promotes Lung Cancer Immunity
Authors: SS Kim, C Doherty, M Moghe, A Rait, KF Pirollo, JB Harford, EH Chang
Cancers, 2022-10-18;14(20):.
Species: Xenograft
Sample Types: Cell Lysates
Applications: Western Blot -
Retinal Pigment Epithelium-Secreted VEGF-A Induces Alpha-2-Macroglobulin Expression in Endothelial Cells
Authors: GL Lehmann, M Ginsberg, DJ Nolan, C Rodríguez, J Martínez-G, S Zeng, AP Voigt, RF Mullins, S Rafii, E Rodriguez-, I Benedicto
Cells, 2022-09-24;11(19):.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Senescent Human Pancreatic Stellate Cells Secrete CXCR2 Agonist CXCLs to Promote Proliferation and Migration of Human Pancreatic Cancer AsPC-1 and MIAPaCa-2 Cell Lines
Authors: T Takikawa, S Hamada, R Matsumoto, Y Tanaka, F Kataoka, A Sasaki, A Masamune
International Journal of Molecular Sciences, 2022-08-17;23(16):.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
The conserved C-terminal residues of FAM83H are required for the recruitment of casein kinase 1 to the keratin cytoskeleton
Authors: T Kuga, N Inoue, K Sometani, S Murataka, M Saraya, R Sugita, T Mikami, Y Takeda, M Taniguchi, K Nishida, N Yamagishi
Scientific Reports, 2022-07-12;12(1):11819.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
NF-kappaB-inducing kinase (NIK) is activated in pancreatic beta-cells but does not contribute to the development of diabetes
Authors: P Xiao, T Takiishi, NM Violato, G Licata, F Dotta, G Sebastiani, L Marselli, SP Singh, M Sze, G Van Loo, E Dejardin, EN Gurzov, AK Cardozo
Cell Death & Disease, 2022-05-19;13(5):476.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Rapid lamellipodial responses by neighbor cells drive epithelial sealing in response to pyroptotic cell death
Authors: A Bonfim-Mel, I Noordstra, S Gupta, AH Chan, MJK Jones, K Schroder, AS Yap
Cell Reports, 2022-02-01;38(5):110316.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Coordinated glucocorticoid receptor and MAFB action induces tolerogenesis and epigenome remodeling in dendritic cells
Authors: O Morante-Pa, L Ciudad, R Micheroli, C de la Call, T Li, G Barbisan, M Houtman, SG Edalat, M Frank-Bert, C Ospelt, E Ballestar
Nucleic Acids Research, 2022-01-11;0(0):.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Effects of 2-Methoxyestradiol, a Main Metabolite of Estradiol on Hepatic ABCA1 Expression in HepG2 Cells
Authors: T Ibata, J Lyu, H Imachi, K Fukunaga, S Sato, T Kobayashi, T Saheki, T Yoshimura, K Murao
Nutrients, 2022-01-11;14(2):.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
The RNA helicase Ddx21 controls Vegfc-driven developmental lymphangiogenesis by balancing endothelial cell ribosome biogenesis and p53 function
Authors: K Koltowska, KS Okuda, M Gloger, M Rondon-Gal, E Mason, J Xuan, S Dudczig, H Chen, H Arnold, R Skoczylas, NI Bower, S Paterson, AK Lagendijk, GJ Baillie, I Leshchiner, C Simons, KA Smith, W Goessling, JK Heath, RB Pearson, E Sanij, S Schulte-Me, BM Hogan
Nature Cell Biology, 2021-11-08;23(11):1136-1147.
Species: Human
Sample Types:
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A spoonful of L-fucose-an efficient therapy for GFUS-CDG, a new glycosylation disorder
Authors: RG Feichtinge, A Hüllen, A Koller, D Kotzot, V Grote, E Rapp, P Hofbauer, K Brugger, C Thiel, JA Mayr, SB Wortmann
Embo Molecular Medicine, 2021-09-01;13(9):e14332.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Progesterone depletion results in Lamin B1 loss and induction of cell death in mouse trophoblast giant cells
Authors: H Morimoto, M Ueno, H Tanabe, T Kono, H Ogawa
PLoS ONE, 2021-07-14;16(7):e0254674.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
ABT?737, a Bcl?2 family inhibitor, has a synergistic effect with apoptosis by inducing urothelial carcinoma cell necroptosis
Authors: R Cheng, X Liu, Z Wang, K Tang
Molecular Medicine Reports, 2021-03-31;23(6):.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
EBF1 drives hallmark B cell gene expression by enabling the interaction of PAX5 with the MLL H3K4 methyltransferase complex
Authors: CE Bullerwell, PP Robichaud, PML Deprez, AP Joy, G Wajnberg, D D'Souza, S Chacko, S Fournier, N Crapoulet, DA Barnett, SM Lewis, RJ Ouellette
Scientific Reports, 2021-01-15;11(1):1537.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Activation of PKC supports the anticancer activity of tigilanol tiglate and related epoxytiglianes
Authors: JK Cullen, GM Boyle, PY Yap, S Elmlinger, JL Simmons, N Broit, J Johns, B Ferguson, LA Maslovskay, AI Savchenko, PM Mirzayans, A Porzelle, PV Bernhardt, VA Gordon, PW Reddell, A Pagani, G Appendino, PG Parsons, CM Williams
Scientific Reports, 2021-01-08;11(1):207.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Aprotinin Inhibits SARS-CoV-2 Replication
Authors: D Bojkova, M Bechtel, KM McLaughlin, JE McGreig, K Klann, C Bellinghau, G Rohde, D Jonigk, P Braubach, S Ciesek, C Münch, MN Wass, M Michaelis, J Cinatl
Cells, 2020-10-30;9(11):.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
The DNA methyltransferase DNMT3A contributes to autophagy long-term memory
Authors: P González-R, M Cheray, J Füllgrabe, M Salli, P Engskog-Vl, L Keane, V Cunha, A Lupa, W Li, Q Ma, K Dreij, MG Rosenfeld, B Joseph
Autophagy, 2020-09-14;0(0):1-19.
Species: Human, Mouse
Sample Types: Cell Lysates
Applications: Western Blot -
Depletion of Csk preferentially reduces the protein level of LynA in a Cbl-dependent manner in cancer cells
Authors: T Kuga, Y Yamane, S Hayashi, M Taniguchi, N Yamaguchi, N Yamagishi
Sci Rep, 2020-05-06;10(1):7621.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Nrf2 activation protects against lithium-induced nephrogenic diabetes insipidus
Authors: S Jobbagy, DA Vitturi, SR Salvatore, MF Pires, P Rowart, DR Emlet, M Ross, S Hahn, C St Croix, SG Wendell, AR Subramanya, AC Straub, RJ Tan, FJ Schopfer
JCI Insight, 2020-01-16;5(1):.
Species: Mouse
Sample Types: Tissue Lysate
Applications: Western Blot -
Receptor Heterodimerization and Co-Receptor Engagement in TLR2 Activation Induced by MIC1 and MIC4 from Toxoplasma gondii
Authors: F Costa Mend, C Duque Lope, R Ricci-Azev, A Sardinha-S, C Figueiredo, AC Paiva Aleg, L L Nohara, A B Carneiro, A Panunto-Ca, I C Almeida, MC Roque-Barr
Int J Mol Sci, 2019-10-10;20(20):.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot -
Blockade of leukemia inhibitory factor as a therapeutic approach to KRAS driven pancreatic cancer
Authors: MT Wang, N Fer, J Galeas, EA Collisson, SE Kim, J Sharib, F McCormick
Nat Commun, 2019-07-11;10(1):3055.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Humanization of the entire murine Mapt gene provides a murine model of pathological human tau propagation
Authors: T Saito, N Mihira, Y Matsuba, H Sasaguri, S Hashimoto, S Narasimhan, B Zhang, S Murayama, M Higuchi, VMY Lee, JQ Trojanowsk, TC Saido
J. Biol. Chem., 2019-07-04;0(0):.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: Western Blot -
Anticancer effects of a non-narcotic opium alkaloid medicine, papaverine, in human glioblastoma cells
Authors: M Inada, M Shindo, K Kobayashi, A Sato, Y Yamamoto, Y Akasaki, K Ichimura, SI Tanuma
PLoS ONE, 2019-05-17;14(5):e0216358.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition
Authors: RC Coll, JR Hill, CJ Day, A Zamoshniko, D Boucher, NL Massey, JL Chitty, JA Fraser, MP Jennings, AAB Robertson, K Schroder
Nat. Chem. Biol., 2019-05-13;15(6):556-559.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Propranolol regulates ERK1/2 signaling pathway and promotes chronic wound healing in diabetic rats
Authors: X Chang, S Li, XD Xue, F Chang
Eur Rev Med Pharmacol Sci, 2019-05-01;23(10):4498-4506.
Species: Rat
Sample Types: Cell Lysates
Applications: Western Blot -
Single-Cell RNA-Sequencing-Based CRISPRi Screening Resolves Molecular Drivers of Early Human Endoderm Development
Authors: RMJ Genga, EM Kernfeld, KM Parsi, TJ Parsons, MJ Ziller, R Maehr
Cell Rep, 2019-04-16;27(3):708-718.e10.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Coenzyme Q10 protects against burn-induced mitochondrial dysfunction and impaired insulin signaling in mouse skeletal muscle
Authors: H Nakazawa, K Ikeda, S Shinozaki, S Yasuhara, YM Yu, JAJ Martyn, RG Tompkins, T Yorozu, S Inoue, M Kaneki
FEBS Open Bio, 2019-01-19;9(2):348-363.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: Western Blot -
Validation of antibody-based tools for galanin research
Authors: SM Brunner, A Koller, J Stockinger, F Locker, S Leis, F Ernst, P Strasser, B Brodowicz, S Ebner, BS Holub, I Rauch, K Graf, R Lang, B Kofler
Peptides, 2018-09-06;120(0):170009.
Species: Human, Mouse
Sample Types: Cell Lysates, Tissue Homogenates
Applications: Western Blot -
Gelatinolytic activity of autocrine matrix metalloproteinase-9 leads to endothelial de-arrangement in Moyamoya disease
Authors: KG Blecharz-L, V Prinz, M Burek, D Frey, T Schenkel, SM Krug, M Fromm, P Vajkoczy
J. Cereb. Blood Flow Metab., 2018-04-10;0(0):271678X187684.
Species: Human
Sample Types: Tissue Lysates
Applications: Western Blot -
MicroRNA miR-27 Inhibits Adenovirus Infection by Suppressing the Expression of SNAP25 and TXN2.
Authors: Machitani M, Sakurai F, Wakabayashi K, Nakatani K, Tachibana M, Mizuguchi H
J Virol, 2017-05-26;91(12):.
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Bim gene dosage is critical in modulating nephron progenitor survival in the absence of microRNAs during kidney development.
Authors: Cerqueira D, Bodnar A, Phua Y, Freer R, Hemker S, Walensky L, Hukriede N, Ho J
FASEB J, 2017-04-26;31(8):3540-3554.
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Quantitative Structure-Cytotoxicity Relationship of Chalcones.
Authors: Sakagami H, Masuda Y, Tomomura M, Yokose S, Uesawa Y, Ikezoe N, Asahara D, Takao K, Kanamoto T, Terakubo S, Kagaya H, Nakashima H, Sugita Y
Anticancer Res, 2017-03-01;37(3):1091-1098.
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Induction of Apoptosis in Human Oral Keratinocyte by Doxorubicin.
Authors: Sakagami H, Okudaira N, Masuda Y, Amano O, Yokose S, Kanda Y, Suguro M, Natori T, Oizumi H, Oizumi T
Anticancer Res, 2017-03-01;37(3):1023-1029.
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Resolution of TLR2-induced inflammation through manipulation of metabolic pathways in Rheumatoid Arthritis
Authors: T McGarry, M Biniecka, W Gao, D Cluxton, M Canavan, S Wade, S Wade, L Gallagher, C Orr, DJ Veale, U Fearon
Sci Rep, 2017-02-22;7(0):43165.
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Sirtuin1-regulated lysine acetylation of p66Shc governs diabetes-induced vascular oxidative stress and endothelial dysfunction.
Authors: Kumar S, Kim Y, Vikram A, Naqvi A, Li Q, Kassan M, Kumar V, Bachschmid M, Jacobs J, Kumar A, Irani K
Proc Natl Acad Sci U S A, 2017-01-30;114(7):1714-1719.
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Plasma Membrane Origin of the Steroidogenic Pool of Cholesterol Used in Hormone-induced Acute Steroid Formation in Leydig Cells.
Authors: Venugopal S, Martinez-Arguelles D, Chebbi S, Hullin-Matsuda F, Kobayashi T, Papadopoulos V
J Biol Chem, 2016-11-03;291(50):26109-26125.
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Hepatic aberrant glycosylation by N-acetylglucosaminyltransferase V accelerates HDL assembly.
Authors: Kamada Y, Kida S, Hirano K, Yamaguchi S, Suzuki A, Hashimoto C, Kimura A, Sato M, Fujii H, Sobajima T, Yamamoto A, Ebisutani Y, Takamatsu S, Shinzaki S, Yoshida Y, Yamada M, Nagasaka H, Takehara T, Miyoshi E
Am J Physiol Gastrointest Liver Physiol, 2016-09-22;311(5):G859-G868.
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Enhancement of Cytotoxicity of Three Apoptosis-inducing Agents Against Human Oral Squamous Cell Carcinoma Cell Line by Benzoxazinotropone.
Authors: Tomikoshi Y, Nomura M, Okudaira N, Sakagami H, Wakabayashi H
In Vivo, 2016-09-10;30(5):645-50.
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Cross-regulation of Phosphodiesterase 1 and Phosphodiesterase 2 Activities Controls Dopamine-mediated Striatal alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Trafficking.
Authors: Song R, Tolentino R, Sobie E, Neves-Zaph S
J Biol Chem, 2016-09-07;291(44):23257-23267.
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Sustained Mutant KIT Activation in the Golgi Complex Is Mediated by PKC-theta in Gastrointestinal Stromal Tumors.
Authors: Kim W, Yun S, Park C, Bauer S, Kim J, Lee M, Kim H
Clin Cancer Res, 2016-07-20;23(3):845-856.
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Letrozole vs estradiol valerate induced PCOS in rats: glycemic, oxidative and inflammatory status assessment.
Authors: Daneasa A, Cucolas C, Lenghel L, Olteanu D, Orasan R, Filip G
Reproduction, 2016-01-20;151(4):401-9.
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MicroRNA Biogenesis and Hedgehog-Patched Signaling Cooperate to Regulate an Important Developmental Transition in Granule Cell Development.
Authors: Constantin L, Constantin M, Wainwright B
Genetics, 2016-01-15;202(3):1105-18.
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Histone Deacetylase Inhibitors Promote Mitochondrial Reactive Oxygen Species Production and Bacterial Clearance by Human Macrophages.
Authors: Ariffin J, das Gupta K, Kapetanovic R, Iyer A, Reid R, Fairlie D, Sweet M
Antimicrob Agents Chemother, 2015-12-28;60(3):1521-9.
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Analysis of the N-terminal region of human MLKL, as well as two distinct MLKL isoforms, reveals new insights into necroptotic cell death.
Authors: Arnez K, Kindlova M, Bokil N, Murphy J, Sweet M, Guncar G
Biosci Rep, 2015-12-24;36(1):e00291.
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Phosphatidylinositol-3,4-Bisphosphate and Its Binding Protein Lamellipodin Regulate Chemotaxis of Malignant B Lymphocytes.
Authors: Li H, Wu X, Hou S, Malek M, Kielkowska A, Noh E, Makondo K, Du Q, Wilkins J, Johnston J, Gibson S, Lin F, Marshall A
J Immunol, 2015-12-22;196(2):586-95.
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Endoplasmic reticulum stress increases AT1R mRNA expression via TIA-1-dependent mechanism.
Authors: Backlund M, Paukku K, Kontula K, Lehtonen J
Nucleic Acids Res, 2015-12-17;0(0):.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Renal stromal miRNAs are required for normal nephrogenesis and glomerular mesangial survival.
Authors: Phua Y, Chu J, Marrone A, Bodnar A, Sims-Lucas S, Ho J
Physiol Rep, 2015-10-01;3(10):.
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SORT1 Mutation Resulting in Sortilin Deficiency and p75(NTR) Upregulation in a Family With Essential Tremor.
Authors: Sanchez E, Bergareche A, Krebs C, Gorostidi A, Makarov V, Ruiz-Martinez J, Chorny A, Lopez de Munain A, Marti-Masso J, Paisan-Ruiz C
ASN Neuro, 2015-08-21;7(4):.
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Alterations of oxidative phosphorylation in meningiomas and peripheral nerve sheath tumors.
Authors: Feichtinger R, Weis S, Mayr J, Zimmermann F, Bogner B, Sperl W, Kofler B
Neuro Oncol, 2015-06-23;18(2):184-94.
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Decreased eIF3e Expression Can Mediate Epithelial-to-Mesenchymal Transition through Activation of the TGFbeta Signaling Pathway.
Authors: Desnoyers G, Frost L, Courteau L, Wall M, Lewis S
Mol Cancer Res, 2015-06-08;13(10):1421-30.
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Loss of Gab1 adaptor protein in hepatocytes aggravates experimental liver fibrosis in mice.
Authors: Kizu T, Yoshida Y, Furuta K, Ogura S, Egawa M, Chatani N, Hamano M, Takemura T, Ezaki H, Kamada Y, Nishida K, Nakaoka Y, Kiso S, Takehara T
Am J Physiol Gastrointest Liver Physiol, 2015-01-23;308(7):G613-24.
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Rab31 and APPL2 enhance FcgammaR-mediated phagocytosis through PI3K/Akt signaling in macrophages.
Authors: Yeo J, Wall A, Luo L, Stow J
Mol Biol Cell, 2015-01-07;26(5):952-65.
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Tricellulin regulates junctional tension of epithelial cells at tricellular contacts through Cdc42.
Authors: Oda Y, Otani T, Ikenouchi J, Furuse M
J Cell Sci, 2014-08-05;127(0):4201-12.
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EDEM2 initiates mammalian glycoprotein ERAD by catalyzing the first mannose trimming step.
Authors: Ninagawa S, Okada T, Sumitomo Y, Kamiya Y, Kato K, Horimoto S, Ishikawa T, Takeda S, Sakuma T, Yamamoto T, Mori K
J Cell Biol, 2014-08-04;206(3):347-56.
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Retrotransposition of long interspersed element 1 induced by methamphetamine or cocaine.
Authors: Okudaira N, Ishizaka Y, Nishio H
J Biol Chem, 2014-07-22;289(37):25476-85.
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Conditional knockout of the leptin receptor in the colonic epithelium revealed the local effects of leptin receptor signaling in the progression of colonic tumors in mice.
Authors: Higurashi T, Endo H, Uchiyama T, Uchiyama S, Yamada E, Ohkubo H, Sakai E, Takahashi H, Maeda S, Wada K, Natsumeda Y, Hippo Y, Nakajima A, Nakagama H
Carcinogenesis, 2014-06-23;35(9):2134-41.
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Pharmacological regulation of SPARC by lovastatin in human trabecular meshwork cells.
Authors: Villarreal G, Chatterjee A, Oh S, Oh D, Rhee D
Invest Ophthalmol Vis Sci, 2014-03-19;55(3):1657-65.
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Forced expression of DNA methyltransferases during oocyte growth accelerates the establishment of methylation imprints but not functional genomic imprinting.
Authors: Hara S, Takano T, Fujikawa T, Yamada M, Wakai T, Kono T, Obata Y
Hum Mol Genet, 2014-03-05;23(14):3853-64.
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Cortactin scaffolds Arp2/3 and WAVE2 at the epithelial zonula adherens.
Authors: Han, Siew Pin, Gambin, Yann, Gomez, Guillerm, Verma, Suzie, Giles, Nichole, Michael, Magdalen, Wu, Selwin K, Guo, Zhong, Johnston, Wayne, Sierecki, Emma, Parton, Robert G, Alexandrov, Kirill, Yap, Alpha S
J Biol Chem, 2014-01-27;289(11):7764-75.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
The productive entry pathway of HIV-1 in macrophages is dependent on endocytosis through lipid rafts containing CD4.
Authors: van Wilgenburg, Bonnie, Moore, Michael, James, William, Cowley, Sally A
PLoS ONE, 2014-01-22;9(1):e86071.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Lipopolysaccharide induces degradation of connexin43 in rat astrocytes via the ubiquitin-proteasome proteolytic pathway.
Authors: Liao C, Jeng C, Wang H, Wang S, Wu J
PLoS ONE, 2013-11-13;8(11):e79350.
Species: Rat
Sample Types: Cell Lysates
Applications: Western Blot -
Nicotine induces the up-regulation of the alpha7-nicotinic receptor (alpha7-nAChR) in human squamous cell lung cancer cells via the Sp1/GATA protein pathway.
Authors: Brown K, Perry H, Lau J, Jones D, Pulliam J, Thornhill B, Crabtree C, Luo H, Chen Y, Dasgupta P
J Biol Chem, 2013-10-02;288(46):33049-59.
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Mechanism of enhancement of radiation-induced cytotoxicity by sorafenib in colorectal cancer.
Authors: Kim Y, Jeung H, Jeong I, Lee K, Rha S, Chung H, Kim G
J Radiat Res, 2012-08-24;54(1):52-60.
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Human TSC-associated renal angiomyolipoma cells are hypersensitive to ER stress.
Authors: Siroky B, Yin H, Babcock J, Lu L, Hellmann A, Dixon B, Quilliam L, Bissler J
Am J Physiol Renal Physiol, 2012-07-11;303(6):F831-44.
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Cell surface expression of the major amyloid-beta peptide (Abeta)-degrading enzyme, neprilysin, depends on phosphorylation by mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK) and dephosphorylation by protein phosphatase 1a.
Authors: Kakiya N, Saito T, Nilsson P, Matsuba Y, Tsubuki S, Takei N, Nawa H, Saido T
J Biol Chem, 2012-07-05;287(35):29362-72.
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Transcriptional regulation of translocator protein (Tspo) via a SINE B2-mediated natural antisense transcript in MA-10 Leydig cells.
Authors: Fan J, Papadopoulos V
Biol Reprod, 2012-05-10;86(5):147, 1-15.
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Hormone-induced 14-3-3gamma adaptor protein regulates steroidogenic acute regulatory protein activity and steroid biosynthesis in MA-10 Leydig cells.
Authors: Aghazadeh Y, Rone M, Blonder J, Ye X, Veenstra T, Hales D, Culty M, Papadopoulos V
J Biol Chem, 2012-03-16;287(19):15380-94.
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Regulation of AT1R expression through HuR by insulin.
Authors: Paukku K, Backlund M, de Boer R, Kalkkinen N, Kontula K, Lehtonen J
Nucleic Acids Res, 2012-02-23;40(12):5250-61.
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N-Acetylglucosaminyltransferase V regulates TGF-beta response in hepatic stellate cells and the progression of steatohepatitis.
Authors: Kamada Y, Mori K, Matsumoto H, Kiso S, Yoshida Y, Shinzaki S, Hiramatsu N, Ishii M, Moriwaki K, Kawada N, Takehara T, Miyoshi E
Glycobiology, 2012-01-30;22(6):778-87.
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The nuclear receptor, Nor-1, markedly increases type II oxidative muscle fibers and resistance to fatigue.
Authors: Pearen M, Eriksson N, Fitzsimmons R, Goode J, Martel N, Andrikopoulos S, Muscat G
Mol Endocrinol, 2012-01-26;26(3):372-84.
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B-cell adaptor for PI3K (BCAP) negatively regulates Toll-like receptor signaling through activation of PI3K.
Authors: Ni M, MacFarlane A, Toft M, Lowell C, Campbell K, Hamerman J
Proc Natl Acad Sci U S A, 2011-12-20;109(1):267-72.
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Tuberin and PRAS40 are anti-apoptotic gatekeepers during early human amniotic fluid stem-cell differentiation.
Authors: Fuchs C, Rosner M, Dolznig H, Mikula M, Kramer N, Hengstschlager M
Hum Mol Genet, 2011-11-16;21(5):1049-61.
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MicroRNA-494 downregulates KIT and inhibits gastrointestinal stromal tumor cell proliferation.
Authors: Kim W, Park M, Kim Y, Tae Y, Yang H, Lee J, Kim H
Clin Cancer Res, 2011-10-31;17(24):7584-94.
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Farnesyltransferase inhibitor FTI-277 reduces mortality of septic mice along with improved bacterial clearance.
Authors: Yang W, Yamada M, Tamura Y, Chang K, Mao J, Zou L, Feng Y, Kida K, Scherrer-Crosbie M, Chao W, Ichinose F, Yu Y, Fischman A, Tompkins R, Yao S, Kaneki M
J Pharmacol Exp Ther, 2011-08-26;339(3):832-41.
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Protein kinase C and NF-kappaB-dependent CD4 downregulation in macrophages induced by T cell-derived soluble factors: consequences for HIV-1 infection.
Authors: Raposo RA, Trudgian DC, Thomas B, van Wilgenburg B, Cowley SA, James W
J. Immunol., 2011-06-10;187(2):748-59.
Species: Human
Sample Types: Cell Culture Supernates
Applications: Western Blot -
Patched1 inhibits epidermal progenitor cell expansion and basal cell carcinoma formation by limiting Igfbp2 activity.
Authors: Villani RM, Adolphe C, Palmer J, Waters MJ, Wainwright BJ
Cancer Prev Res (Phila), 2010-09-21;3(10):1222-34.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: Western Blot -
Cadherin adhesion receptors orient the mitotic spindle during symmetric cell division in mammalian epithelia.
Authors: den Elzen N, Buttery CV, Maddugoda MP, Ren G, Yap AS
Mol. Biol. Cell, 2009-06-24;20(16):3740-50.
Species: Canine
Sample Types: Cell Lysates
Applications: Western Blot -
Post-transcriptional silencing of CCR3 downregulates IL-4 stimulated release of eotaxin-3 (CCL26) and other CCR3 ligands in alveolar type II cells.
Authors: Taka E, Errahali YJ, Abonyo BO, Bauer DM, Heiman AS
Cytokine, 2008-11-26;44(3):342-51.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Reduction of brain metastases in plasminogen activator inhibitor-1-deficient mice with transgenic ocular tumors.
Authors: Maillard CM, Bouquet C, Petitjean MM, Mestdagt M, Frau E, Jost M, Masset AM, Opolon PH, Beermann F, Abitbol MM, Foidart JM, Perricaudet MJ, Noel AC
Carcinogenesis, 2008-08-27;29(11):2236-42.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: Western Blot -
Modulation of eotaxin-3 (CCL26) in alveolar type II epithelial cells.
Authors: Abonyo BO, Lebby KD, Tonry JH, Ahmad M, Heiman AS
Cytokine, 2007-03-09;36(5):237-44.
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Nitric oxide-induced apoptosis in RAW 264.7 macrophages is mediated by endoplasmic reticulum stress pathway involving ATF6 and CHOP.
Authors: Gotoh T, Oyadomari S, Mori K, Mori M
J. Biol. Chem., 2002-01-22;277(14):12343-50.
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