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KN 93 phosphate

Catalog #: 5215
5 Citations Datasheet / COA / SDS
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5215/1
KN 93 phosphate | CAS No. 1188890-41-6 | CaM Kinase Inhibitors
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Description: CaM kinase II inhibitor; water soluble version of KN 93 (Cat. No. 1278)

Chemical Name: N-[2-[[[3-(4-Chlorophenyl)-2-propenyl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulphonamide phosphate

Purity: ≥98%

Product Details
Citations (5)
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Biological Activity

KN 93 phosphate is a CaM kinase II inhibitor; water soluble version of KN 93 (Cat. No. 1278).

Technical Data

M.Wt:
599.03
Formula:
C26H29ClN2O4S.H3PO4
Solubility:
Soluble to 10 mM in water
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1188890-41-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. KN-93, an inhibitor of multifunctional Ca2+/calmodulin-dependent protein kinase, decreases early afterdepolarizations in rabbit heart.
    Anderson et al.
    J.Pharmacol.Exp.Ther., 1998;287:996
  2. The newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces DA content in PC12h cells.
    Sumi et al.
    Biochem.Biophys.Res.Comm., 1991;181:968
  3. Microwave-assisted synthesis of KN-93, a potent and selective inhibitor or Ca2+/Calmoduline-dependent protein kinase II.
    Bruno et al.
    Synthesis, 2010;24:4193
  4. KN-93 (2-[N-(2-Hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]-amino-N-(4-chlorocinnamyl)-N-methylbenzylamine), a calcium/calmodulin-dependent protein kinase II inhibitor, is a direct extracellular blocker of voltage-gated
    Rezazadeh et al.
    J.Pharmacol.Exp.Ther., 2006;317:292

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Citations for KN 93 phosphate

The citations listed below are publications that use Tocris products. Selected citations for KN 93 phosphate include:

5 Citations: Showing 1 - 5

  1. Effects of HIV-1 Tat on oligodendrocyte viability are mediated by CaMKIIβ-GSK3β interactions.
    Authors: Kurt F Et al.
    J Neurochem  2019;149:98-110
  2. Modulation of AMPA receptor surface diffusion restores hippocampal plasticity and memory in Huntington's disease models.
    Authors: Zhang Et al.
    Nat Commun  2018;9:4272
  3. Synaptic activity suppresses expression of neurogenic differentiation factor 2 in an NMDA receptor-dependent manner.
    Authors: Fading Et al.
    Synapse  2017;71
  4. Targeted Intron Retention and Excision for Rapid Gene Regulation in Response to Neuronal Activity.
    Authors: Mauger Et al.
    Neuron  2016;92:1266
  5. Calcium-activated chloride channel ANO1 promotes breast cancer progression by activating EGFR and CAMK signaling.
    Authors: Mark Et al.
    Proc Natl Acad Sci U S A  2013;110:E1026-34

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