Home / Calcium Binding Protein Modulator Inhibitors / KN 93

KN 93

Catalog #: 1278
23 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
1278/1
KN 93 | CAS No. 139298-40-1 | Calcium Binding Protein Modulator Inhibitors
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Description: CaM kinase II inhibitor; also K+ channel blocker (KV)

Chemical Name: N-[2-[[[3-(4-Chlorophenyl)-2-propenyl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulphonamide

Purity: ≥98%

Product Details
Citations (23)
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Biological Activity

KN 93 is a potent, cell permeable inhibitor of CaM kinase II (IC50 = 0.37 μM). Also a direct extracellular open channel blocker of voltage-gated potassium channels (IC50 = 307 nM for KV1.5) and abolishes IKr in ventricular myocytes (IC50 = 102.6 nM) independently of CaM kinase II inhibition.

Water soluble form and Negative Control also available.

Technical Data

M.Wt:
501.04
Formula:
C26H29ClN2O4S
Solubility:
Soluble to 100 mM in DMSO with gentle warming
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
139298-40-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for KN 93

The citations listed below are publications that use Tocris products. Selected citations for KN 93 include:

23 Citations: Showing 1 - 10

  1. An Intrinsic Epigenetic Barrier for Functional Axon Regeneration.
    Authors: Weng Et al.
    Neuron  2017;94:337
  2. WNT5a is required for normal ovarian follicle development and antagonizes g.tropin responsiveness in granulosa cells by suppressing canonical WNT signaling.
    Authors: Abedini Et al.
    FASEB J  2016;30:1534
  3. Ca(2+)/calmodulin-dependent protein kinase II interacts with group I metabotropic glutamate and facilitates receptor endocytosis and ERK1/2 signaling: role of β-amyloid.
    Authors: Raka Et al.
    Mol Brain  2015;8:21
  4. Modulation of P2X4/P2X7/Pannexin-1 sensitivity to extracellular ATP via iverm. induces a non-apoptotic and inflammatory form of cancer cell death.
    Authors: Draganov Et al.
    Apoptosis  2015;5:16222
  5. Evolutionary and functional perspectives on signaling from neuronal surface to nucleus.
    Authors: Cohen Et al.
    PLoS One  2015;460:88
  6. Synapse-specific compartmentalization of signaling cascades for LTP induction in CA3 interneurons.
    Authors: Galván Et al.
    Neuroscience  2015;290:332
  7. Calcium signals inhibition sensitizes ovarian carcinoma cells to anti-Bcl-xL strategies through Mcl-1 down-regulation.
    Authors: Bonnefond Et al.
    Oncoscience  2015;20:535
  8. Melanoma brain colonization involves the emergence of a brain-adaptive phenotype.
    Authors: Nygaard Et al.
    Biochem Biophys Res Commun  2015;1:82
  9. Activation of Phosphatidylinositol-Linked DA Receptors Induces a Facilitation of Glutamate-Mediated Synaptic Transmission in the Lateral Entorhinal Cortex.
    Authors: Glovaci and Chapman
    PLoS One  2015;10:e0131948
  10. SynGAP regulates protein synthesis and homeostatic synaptic plasticity in developing cortical networks.
    Authors: Wang Et al.
    PLoS One  2014;8:e83941
  11. Non-cell-autonomous mechanism of activity-dependent neurotransmitter switching.
    Authors: Guemez-Gamboa Et al.
    Neuron  2014;82:1004
  12. Oestrogen upregulates the sarcoplasmic reticulum Ca(2+) ATPase pump in coronary arteries.
    Authors: Hill and Muldrew
    Clin Exp Pharmacol Physiol  2014;41:430
  13. Involvement of amygdalar protein kinase A, but not calcium/calmodulin-dependent protein kinase II, in the reconsolidation of cocaine-related contextual memories in rats.
    Authors: Arguello Et al.
    Psychopharmacology (Berl)  2014;231:55
  14. CaMKII phosphorylation of neuroligin-1 regulates excitatory synapses.
    Authors: Bemben Et al.
    Nat Neurosci  2014;17:56
  15. Acute SimV. inhibits K ATP channels of porcine coronary artery myocytes.
    Authors: Seto Et al.
    Biochem Pharmacol  2013;8:e66404
  16. AMP-activated protein kinase as regulator of P2Y(6) receptor-induced Ins secretion in mouse pancreatic β-cells.
    Authors: Balasubramanian Et al.
    J Neurosci  2013;85:991
  17. Increased neuronal activity fragments the Golgi complex.
    Authors: Thayer Et al.
    Proc Natl Acad Sci U S A  2013;110:1482
  18. Interaction between αCaMKII and GluN2B controls ERK-dependent plasticity.
    Authors: Gaamouch Et al.
    J Neurosci  2012;32:10767
  19. Calcium/calmodulin-dependent protein kinase II mediates group I metabotropic glutamate receptor-dependent protein synthesis and long-term depression in rat hippocampus.
    Authors: Mockett Et al.
    J Neurosci  2011;31:7380
  20. HyperDArgic tone erodes prefrontal long-term potential via a D2 receptor-operated protein phosphatase gate.
    Authors: Xu Et al.
    MBio  2009;29:14086
  21. Calmodulin kinase II initiates arrhythmogenicity during metabolic acidification in murine hearts.
    Authors: Pedersen Et al.
    Acta Physiol (Oxf)  2009;197:13
  22. Synapse-specific adaptations to inactivity in hippocampal circuits achieve homeostatic gain control while dampening network reverberation.
    Authors: Kim and Tsien
    Neuron  2008;58:925
  23. NMDA receptor activation potentiates inhibitory transmission through GABA receptor-associated protein-dependent exocytosis of GABA(A) receptors.
    Authors: Marsden Et al.
    J Neurosci  2007;27:14326

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