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Opicapone

Catalog #: 7668 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7668/50
7668/10
Opicapone | CAS No. 923287-50-7 | Catechol O-Methyltransferase (COMT) Inhibitors
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Description: COMT inhibitor

Chemical Name: 5-[3-(2,5-Dichloro-4,6-dimethyl-1-oxido-3-pyridinyl)-1,2,4-oxadiazol-5-yl]-3-nitro-1,2-benzenediol

Purity: ≥98%

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Biological Activity

Opicapone is a reversible catechol O-methyltransferase inhibitor (COMT) inhibitor (IC50 = 224 nM). Decreases the ATP content and mitochondrial membrane potential in cells (IC50 values are 98 μM and 181 μM respectively). When administered with L-DOPA (Cat. No. 3788) it attenuates Parkinson's-like symptoms in an MPTP-induced animal model.

Technical Data

M.Wt:
413.17
Formula:
C15H10Cl2N4O6
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
923287-50-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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