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PMSF

Catalog #: 4486
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4486/50
PMSF | CAS No. 329-98-6 | Additional Synthetic Protease Inhibitors
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Description: Non-selective protease inhibitor; also blocks anandamide metabolism

Chemical Name: Phenylmethylsulfonyl fluoride

Purity: ≥98%

Product Details
Citations (3)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

PMSF is a non-selective protease inhibitor; irreversibly sulfonates key active site serine residues in serine proteases, acetylcholinesterases, and thiol proteases. Blocks metabolism of anandamide (Cat. No. 1339) in a rodent model of cannabimimetic activity. Unstable in water (t 1/2 ~ 60 mins at pH 7.5). Brain penetrant.

Technical Data

M.Wt:
174.19
Formula:
C7H7FO2S
Solubility:
Soluble to 100 mM in ethanol and to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
329-98-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Reconstitution Calculator

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Citations for PMSF

The citations listed below are publications that use Tocris products. Selected citations for PMSF include:

3 Citations: Showing 1 - 3

  1. Structural basis of selective cannabinoid CB2 receptor activation.
    Authors: Partha Et al.
    Nat Commun  2023;14:1447
  2. A simple protocol to produce mature human-induced pluripotent stem cell-derived cardiomyocytes.
    Authors: Yingqiong Et al.
    STAR Protoc  2021;2:100912
  3. Rapid assessment of DCLK1 inhibitors using a peptide substrate mobility shift assay.
    Authors: Yan Et al.
    STAR Protoc  2021;2:100587

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