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SJ 10542

Catalog #: 7727 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7727/2
SJ 10542 | CAS No. 2789678-92-6 | Active Degraders
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Description: Potent and selective JAK2/3 Degrader (PROTAC®)

Chemical Name: 4-((4-(1-(3-(Cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N-(3-(4-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperazin-1-yl)propyl)benzamide

Purity: ≥97%

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Biological Activity

SJ 10542 is a potent and selective JAK2/3 Degrader (PROTAC®) (DC50 values are 11 nM and 14 nM for JAK3 and JAK2, respectively), it uses a phenyl glutarimide (PG) ligand as the cereblon (CRBN) recruiter. SJ 10542 displays high selectivity over GSPT1 and other members of the JAK family. SJ 10542 is active in cytotoxicity assays with PDX models (IC50 values <120 nM).

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data

M.Wt:
818.96
Formula:
C41H46N12O5S
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
2789678-92-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from St. Jude Children's Research Hospital

Product Datasheets

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