Active Degraders: Products

Degraders are a way to knock down target proteins within cells. They are made up of binding moieties for an E3 ubiquitin ligase and a target protein joined by a linker. These hybrid molecules induce selective, proteasome-dependent degradation of target proteins.

"Active Degraders" has 87 results in Products.
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dTAGV-1 

Potent and selective degrader of mutant FKBP12F36V fusion proteins

dTAG-13 

Degrades mutant FKBP12F36V fusion proteins; useful alternative to genetic methods for target validation

5-Ph-IAA 

Selective and potent TAG Degrader for auxin-inducible degron 2 system

MZ 1 

(+)-JQ1 based Degrader (PROTAC®) that preferentially degrades BRD4

dTAG-47 

Degrades mutant FKBP12F36V fusion proteins; useful alternative to genetic methods for target validation

dBRD9 

Potent and selective BRD9 Degrader (PROTAC®)

aTAG 4531 

Degrader of MTH1 fusion proteins for use within the aTAG system

ZNL 02-096 

Potent and selective Wee1 Degrader (PROTAC®)

xStAx-VHLL 

Selective peptide-based β-catenin Degrader (PROTAC®)

dBET1 

(+)-JQ1 based Degrader (PROTAC®) targeting BET bromodomains, active in vivo

dTAG-7 

First generation Degrader for mutant FKBP12F36V fusion proteins; useful alternative to genetic methods for target validation

dBRD9-A 

Potent BRD9 Degrader (PROTAC®)

dBET6 

Potent and selective (+)-JQ1 based Degrader (PROTAC®) targeting BET bromodomains, active in vivo

CRBN-6-5-5-VHL 

Potent and selective cereblon Degrader (PROTAC®); cell-permeable

DD 03-171 

Potent and selective BTK Degrader (PROTAC®)

ARCC 4 

Potent and selective androgen receptor Degrader (PROTAC®)

TBK1 PROTAC® 3i 

Potent TANK-binding kinase 1 (TBK1) PROTAC®

SJF 1528 

Potent EGFR PROTAC® Degrader; also degrades HER2

dTAGV-1 hydrochloride 

Hydrochloride salt of dTAGV-1 (Cat. No. 6914); suitable for in vivo use

LC 2 

Selective KRAS Degrader (PROTAC®)

MD13 

Potent MIF Degrader (PROTAC®)

JQAD1 

Potent and selective EP300 Degrader (PROTAC®)

BromoTag® AGB1 

Potent and selective Degrader of Brd4BD2 L387A fusion proteins (BromoTag®)

AT 1 

(+)-JQ1 based PROTAC® with selectivity for BRD4

CM 11 

Homo-PROTAC® for self-degradation of pVHL30

TL 12-186 

Multikinase Degrader (PROTAC®)

THAL SNS 032 

Potent and selective Cdk9 Degrader (PROTAC®)

dTRIM 24 

TRIM24 Degrader (PROTAC®)

TL 13-12 

Selective ALK Degrader (PROTAC®)

TL 13-112 

Selective ALK Degrader (PROTAC®)

BSJ-03-123 

Selective Cdk6 Degrader (PROTAC®)

VZ 185 

Potent and selective BRD7/9 Degrader (PROTAC®)

BSJ-04-132 

Selective Cdk4 Degrader (PROTAC®)

BSJ-03-204 

Selective Cdk4/6 Degrader (PROTAC®

aTAG 2139 

Degrader of MTH1 fusion proteins for use within the aTAG system

SNIPER(ER)-87 

Potent and selective ERα Degrader (SNIPER)

NR 7h 

Potent and selective p38α and p38β Degrader (PROTAC®); active in vivo

CRBN PROTAC® 14a 

Cereblon Degrader (PROTAC®)

ARV 771 

Potent BET bromodomain PROTAC®; also degrades BRD-tagged chimeric antigen receptors (CAR) in T cells

Gefitinib-based PROTAC® 3 

Potent EGFR PROTAC® Degrader

SJF 1521 

Selective EGFR PROTAC® Degrader

GMB 475 

BCR-ABL1 kinase PROTAC® Degrader

SJF 8240 

c-MET PROTAC®; also degrades exon-14-deleted c-MET

SJFδ 

Potent and selective p38δ PROTAC®

SJFα 

Potent and selective p38α PROTAC®

α1A-AR Degrader 9c 

Selective α1A adrenergic receptor Degrader (PROTAC®)

FAM-DEALA-Hyp-YIPD 

Fluorescent HIF-1α peptide; can be used to evaluate the effect of VHL binding on degradation activity

JH-XI-10-02 

CDK8 Degrader (PROTAC®)

FC 11 

Highly potent focal adhesion kinase (FAK) Degrader (PROTAC®)

BRD PHOTAC-I-3 

Photoswitchable BET bromodomain Degrader (PHOTAC)
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