TC-N 1752
Chemical Name: N-[2-Methyl-3-[[4-[4-[[4-(trifluoromethoxy)phenyl]methoxy]-1-piperidinyl]-1,3,5-triazin-2-yl]amino]phenyl]acetamide
Purity: ≥99%
Biological Activity
TC-N 1752 is a human NaV channel inhibitor (IC50 values are 0.17, 0.3, 0.4, 1.1 and 1.6 μM at hNaV1.7, hNaV1.3, hNaV1.4, hNaV1.5 and hNav1.9 respectively). Also inhibits tetrodotoxin-sensitive sodium channels. Displays analgesic efficacy in the formalin pain model.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Biophysical and pharmacological characterization of Nav1.9 voltage dependent sodium channels stably expressed in HEK-293 cells.
Lin et al.
PLoS One., 2016;11 -
Identification of a potent, state-dependent inhibitor of Nav1.7 with oral efficacy in the formalin model of persistent pain.
Bregman et al.
J.Med.Chem., 2011;54:4427
Product Datasheets
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Citations for TC-N 1752
The citations listed below are publications that use Tocris products. Selected citations for TC-N 1752 include:
2 Citations: Showing 1 - 2
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TRPM4 mediates a subthreshold membrane potential oscillation in respiratory chemoreceptor neurons that drives pacemaker firing and breathing.
Authors: Douglas A Et al.
Cell Rep 2021;34:108714
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Modeling nociception in zebrafish: a way forward for unbiased analgesic discovery.
Authors: Curtright Et al.
PLoS One 2015;10:e0116766
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