UK 14,304
Chemical Name: 5-Bromo-6-(2-imidazolin-2-ylamino)quinoxaline
Biological Activity
UK 14,304 is a full α2 adrenergic agonist. Centrally active following systemic administration in vivo.Water-soluble Salt also available.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Specific [3H]UK-14,304 binding in human cortex occurs at multiple high affinity states with α2-adrenergic selectivity and different affinities for GTP.
Andorn et al.
Life Sci., 1988;43:1805 -
Gene targeting - homing in on α2-adrenoceptor-subtype function.
Macdonald et al.
TiPS, 1997;18:211 -
Effects of alpha-2 adrenoceptor agonists and antagonists on circling behavior in rats with unilateral 6-hydroxyDA lesions of the nigrostriatal pathway.
Chopin et al.
J.Pharmacol.Exp.Ther., 1999;288:798 -
Effects of alpha-2 adrenoceptor agonists and antagonists on circling behavior in rats with unilateral 6-hydroxyDA lesions of the nigrostriatal pathway.
Chopin et al.
J.Pharmacol.Exp.Ther., 1999;288:798
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Citations for UK 14,304
The citations listed below are publications that use Tocris products. Selected citations for UK 14,304 include:
4 Citations: Showing 1 - 4
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A Differential Hypofunctionality of Gαi Proteins Occurs in Adolescent Idiopathic Scoliosis and Correlates with the Risk of Disease Progression.
Authors: Akoume Et al.
Sci Rep 2019;9:10074
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μ-Opioid receptor activation and noradrenaline transport inhibition by tapen. in rat single locus coeruleus neurons.
Authors: Sadeghi Et al.
J Pharmacol Exp Ther 2015;172:460
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MT2 receptors mediate the inhibitory effects of melatonin on nitric oxide-induced relaxation of porcine isolated coronary arteries.
Authors: Tunstall Et al.
J Neurosci 2011;336:127
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The NK1 receptor mediates both the hyperalgesia and the resistance to mor. in mice lacking noradrenaline.
Authors: Jasmin Et al.
Proc Natl Acad Sci U S A 2002;99:1029
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