UK 14,304 tartrate
Discontinued Product
Chemical Name: 5-Bromo-6-(2-imidazolin-2-ylamino)quinoxaline tartrate
Purity: ≥99%
Biological Activity
UK 14,304 tartrate is a water-soluble form of UK 14,304 (Cat. No. 0425). Full α2 adrenergic agonist. Centrally active following systemic administration in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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UK-14,304, a potent and selective alpha2-gonist for the characterisation of alpha-adrenoceptor subtypes.
Cambridge
Eur.J.Pharmacol., 1981;72:413 -
Specific [3H]UK-14,304 binding in human cortex occurs at multiple high affinity states with α2-adrenergic selectivity and different affinities for GTP.
Andorn et al.
Life Sci., 1988;43:1805 -
Gene targeting - homing in on α2-adrenoceptor-subtype function.
Macdonald et al.
TiPS, 1997;18:211 -
Effects of alpha-2 adrenoceptor agonists and antagonists on circling behavior in rats with unilateral 6-hydroxyDA lesions of the nigrostriatal pathway.
Chopin et al.
J.Pharmacol.Exp.Ther., 1999;288:798
Product Datasheets
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Citation for UK 14,304 tartrate
The citations listed below are publications that use Tocris products. Selected citations for UK 14,304 tartrate include:
1 Citation: Showing 1 - 1
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Dorsal BNST α2A-Adrenergic Receptors Produce HCN-Dependent Excitatory Actions That Initiate Anxiogenic Behaviors.
Authors: Harris Et al.
J Neurosci 2018;38:8922
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