BOK: Products

BOK (Bcl-2-related Ovarian Killer) is a 23-kDa pro-apoptotic member of the Bcl-2 family of proteins. BOK has three conserved Bcl-2 homology domains (BH1, 2, and 3) and a C-terminal transmembrane domain, but does not contain the anti-apoptotic BH4 domain. BOK interacts strongly with some anti-apoptotic Bcl-2 proteins (Mcl-1, BHRF1, and A1) and not at all with pro-apoptotic Bcl-2 proteins. The tissue distribution of BOK is restricted to reproductive tissues and it is highly expressed in ovary, testis, and uterus.