Miz-1/ZBTB17: Products

Miz-1 (Myc-interacting zinc finger protein 1; also ZBTB17) is an 88 kDa, DNA-binding protein that belongs to the Kruppel C2H2-type zinc finger protein family. Human Miz-1 is 803 amino acids (aa) in length, and contains a POZ domain (aa 1-104), two Myc-interaction segments (aa 269-308 & 637-718), and 12 C2H2-type zinc finger motifs (aa 306-637); also, there is one alternate splice form that shows an eight aa substitution for Thr769. Miz-1 induces cell arrest at G₁, an effect mediated by its activation of the gene coding for p15^INK4b. This effect is blocked by Myc, which displaces transcriptional coactivators bound to Miz-1. Notably, although the downregulation of Miz-1 may contribute to Myc-induced cell transformation, the deactivation of Miz-1 is absolutely essential for Myc-induced apoptosis. Over aa 1-188, human Miz-1 is 85% aa identical to mouse Miz-1.