"mek1/2" has 4 results in Resources.

The 90 kDa ribosomal protein S6 kinases (RSK1-4) are a family of broadly expressed serine/threonine kinases activated in response to mitogenic stimuli, including growth factors and tumor-promoting phorbol esters.1 The RSK family is positioned downstream of the Raf-MEK-ERK signal transduction module. RSKs are directly phosphorylated by extracellular signal-regulated kinase-1 (ERK1) and ERK2,2...

Analyte Phospho-Specific Antibodies Affinity Purified Polyclonal Antibodies (Total) Monoclonal Antibodies (Total) Labeled Antibodies (Total) Akt (S473) AF887 (S473) AF2055 MAB2055   Akt (T308)   AF2055 MAB2055   AMPK alpha1 (T174)   AF3197 MAB3197   AMPK alpha2...

There is great interest in identifying downstream T cell responses following immune checkpoint blockade to direct more effective treatments and better-informed therapeutic decisions. R&D Systems and Tocris offer a wide selection of reagents, kits, and assays that will allow you to explore, modulate, and validate T cell responses downstream of immune checkpoint blockade. Immune Checkpoint...

Its Role in Growth Factor Signaling and Cancer Contents Upstream from ERK The Core Module Downstream from ERK Conclusions References Growth factors, through receptor tyrosine kinases, recruit a large network of signaling proteins to execute their cellular programs. The first of these networks to be discovered was the Ras-Raf-ERK signal transduction cascade, defined by Extracellular...