Home / Indoleamine 2,3 Dioxygenase Inhibitors / 1-Methyl-D-tryptophan

1-Methyl-D-tryptophan

Catalog #: 5698
1 Citation Datasheet / COA / SDS
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1-Methyl-D-tryptophan | CAS No. 110117-83-4 | Indoleamine 2,3 Dioxygenase Inhibitors
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Description: Indoleamine 2,3-dioxygenase (IDO) inhibitor
Alternative Names: 1MT

Purity: ≥97%

Product Details
Citations (1)
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Biological Activity

1-Methyl-D-tryptophan is an indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50 = 7 μM); disrupts tryptophan catabolism. Enhances the antitumor and antiviral immunoresponses of CD8+ T-cells in vitro. Reduces tumor volume in mice with xenografts overexpressing IDO.

Technical Data

M.Wt:
218.25
Formula:
C12H14N2O2
Solubility:
Soluble to 5 mM in water with gentle warming
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
110117-83-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Effects of indoleamine 2,3-dioxygenase inhibitor in non-Hodgkin lymphoma model mice.
    Nakamura et al.
    Int.J.Hematol., 2015;102:327
  2. Suppression of immunodominant antitumor and antiviral CD8+ T cell responses by indoleamine 2,3-dioxygenase.
    Rytelewski, Mateusz, Meilleur, Courtney, Yekta, Maryam A, Szabo, Peter A, Garg, Nitan, Schell, Todd D, Jevnikar, Anthony, Sharif, Shayan, Singh, Bhagirat, Haeryfar, S M Mans
    PLoS ONE, 2014-02-28;9(2):e90439.

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Citation for 1-Methyl-D-tryptophan

The citations listed below are publications that use Tocris products. Selected citations for 1-Methyl-D-tryptophan include:

1 Citation: Showing 1 - 1

  1. Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39.
    Authors: Howard L Et al.
    Nat Neurosci  2019;22:729-740

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