Home / 5-HT2C Receptor Agonists / 1-Methylpsilocin

1-Methylpsilocin

Catalog #: 3017
1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3017/10
3017/50
1-Methylpsilocin | CAS No. 1465-16-3 | 5-HT2C Receptor Agonists
1 Image
Description: Potent and selective 5-HT2C agonist

Chemical Name: 3-[2-(Dimethylamino)ethyl]-1-methylindol-4-ol

Purity: ≥99%

Product Details
Citations (1)
Supplemental Products
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

1-Methylpsilocin is a potent and selective 5-HT2C agonist (IC50 values are 12 and 633 nM for 5-HT2C and 5-HT2A receptors respectively). Displays high affinity for the 5-HT2B receptor (Ki = 38 nM) but acts as an inverse agonist. Active in vivo; inhibits scratching in a mouse model of OCD.

Technical Data

M.Wt:
218.29
Formula:
C13H18N2O
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
1465-16-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. SAR of psilocybin analogs: discovery of a selective 5-HT2C agonist.
    Sard et al.
    Bioorg.Med.Chem.Letts., 2005;15:4559

Product Datasheets

COA view current batch
Or select another batch:
View Batch
SDS
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citation for 1-Methylpsilocin

The citations listed below are publications that use Tocris products. Selected citations for 1-Methylpsilocin include:

1 Citation: Showing 1 - 1

  1. Differential contributions of serotonin receptors to the behavioral effects of indoleamine hallucinogens in mice.
    Authors: Halberstadt Et al.
    J.Psychopharmacol.  2011;25:1548

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for 1-Methylpsilocin

There are currently no reviews for this product. Be the first to review 1-Methylpsilocin and earn rewards!

Have you used 1-Methylpsilocin?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.