16,16-Dimethyl Prostaglandin E2
Chemical Name: (5Z,11α,13E,15R)-11,15-Dihydroxy-16,16-dimethyl-9-oxo-prosta-5,13-dien-1oic acid
Purity: ≥98%
Biological Activity
16,16-Dimethyl Prostaglandin E2 is a synthetic derivative of prostaglandin E2 (Cat. No. 2296). Increases embryonic stem cell (ESC) hematopoietic colony formation in mouse bone marrow. Also induces an increase in hematopoietic stem cell (HSC) numbers and enhances Wnt activity within the HSC population in zebrafish embryos.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Prostaglandin E2 increases lentiviral vector transduction efficiency of adult human hematopoietic stem and progenitor cells.
Heffner et al.
Mol.Ther, 2018;26:320 -
Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis.
North et al.
Nature., 2007;447:1007 -
Prostaglandin E2: making more of your marrow.
Lord et al.
Cell Cycle., 2007;6:3054 -
Genetic interaction of PGE2 and wnt signaling regulates developmental specification of stem cells and regeneration.
Goessling et al.
Cell., 2009;136:1136
Product Datasheets
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Citations for 16,16-Dimethyl Prostaglandin E2
The citations listed below are publications that use Tocris products. Selected citations for 16,16-Dimethyl Prostaglandin E2 include:
3 Citations: Showing 1 - 3
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COX2 regulates senescence secretome composition and senescence surveillance through PGE2.
Authors: Yoko Et al.
Cell Rep 2021;34:108860
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Prostaglandin E2 is essential for efficacious skeletal muscle stem-cell function, augmenting regeneration and strength.
Authors: Helen M Et al.
Proc Natl Acad Sci U S A 2017;114:6675-6684
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Prostaglandin E2 promotes MYCN non-amplified neuroblastoma cell survival via β-catenin stabilization.
Authors: Jansen Et al.
Oncotarget 2015;19:210
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