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4-Octyl itaconate

Catalog #: 6662
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6662/10
6662/50
4-Octyl itaconate | CAS No. 3133-16-2 | Nrf2 Activators
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Description: Nrf2 activator; cell permeable

Chemical Name: 2-Methylenebutanedioic acid 4-octyl ester

Purity: ≥98%

Product Details
Citations (2)
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Biological Activity

4-Octyl itaconate activates Nrf2. Inhibits LPS-induced increases in IL-1β mRNA, HIF-1α and IL-10 in macrophages. Decreases cytokine production in response to LPS in mice and prolongs survival. Cell permeable.

Technical Data

M.Wt:
242.31
Formula:
C13H22O4
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
3133-16-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for 4-Octyl itaconate

The citations listed below are publications that use Tocris products. Selected citations for 4-Octyl itaconate include:

2 Citations: Showing 1 - 2

  1. Itaconate and Its Derivatives Repress Early Myogenesis In Vitro and In Vivo.
    Authors: Matthew A Et al.
    Front Immunol  2022;13:748375
  2. Itaconate prevents abdominal aortic aneurysm formation through inhibiting inflammation via activation of Nrf2.
    Authors: Yang Et al.
    EBioMedicine  2020;57:102832

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