8-Chloroadenosine

Catalog # Availability Size / Price Qty
4436/10
4436/50
8-Chloroadenosine | CAS No. 34408-14-5 | DNA, RNA and Protein Synthesis Inhibitors
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Description: Cytotoxic nucleoside analog; inhibits RNA synthesis

Chemical Name: 6-Amino-8-chloropurine riboside

Purity: ≥98%

Product Details
Citations (1)
Reviews

Biological Activity

8-Chloroadenosine is a nucleoside analog; metabolized in vivo to 8-Chloro-ATP. Incorporates into RNA during transcription and inhibits RNA synthesis. Exhibits cytotoxicity in MM.1S, RPMI-8226 and U266 cancer cell lines; induces G2/M cell cycle arrest and mitotic catastrophe in A549 and H1299 cells.

Technical Data

M.Wt:
301.69
Formula:
C10H12ClN5O4
Solubility:
Soluble to 20 mM in water with gentle warming and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
34408-14-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for 8-Chloroadenosine

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