A 1120
Chemical Name: 2-(4-(2-(Trifluoromethyl)phenyl)piperidine-1-carboxamido)benzoic acid
Purity: ≥99%
Biological Activity
A 1120 is a high affinity retinol-binding protein 4 (RBP4) ligand (Ki = 8.3 nM); non-retinoid. Selective against a range of different cellular targets. As efficacious as fenretinide (Cat. No. 1396) in the reduction of serum RBP4 and retinol. Displaces transthyretin (TTR) from RBP4-TTR complexes.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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All-trans retinoic acid lowers serum retinol-binding protein 4 concentrations and increases Ins sensitivity in diabetic mice.
Manolescu et al.
J.Nutr., 2009;140:311 -
Identification and characterization of a non-retinoid ligand for retinol-binding protein 4 which lowers serum retinol-binding protein 4 levels in vivo.
Motani et al.
J.Biol.Chem., 2009;284:7673
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Citation for A 1120
The citations listed below are publications that use Tocris products. Selected citations for A 1120 include:
1 Citation: Showing 1 - 1
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Transgenic Mice Over-Expressing RBP4 Have RBP4-Dependent and Light-Independent Retinal Degeneration.
Authors: Du Et al.
Invest Ophthalmol Vis Sci 2017;58:4375?4383
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