A 61603 hydrobromide
Chemical Name: N-[5-(4,5-Dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl]methanesulfonamide hydrobromide
Biological Activity
A 61603 hydrobromide is a potent α-adrenoceptor agonist that is at least 35-fold more potent at α1A than at α1B or α1D sites. Induces dose response increases in spontaneous Ca2+ transients in rat ventricular myocytes in vitro (EC50 = 6.9 nmol/L).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
Receptor subtype involved in α1A-adrenergic receptor-mediated Ca2+ signaling in cardiomyocytes.
Luo et al.
Acta.Pharmacol.Sin., 2007;28:968 -
Synthesis and in vitro characterisation of N-[5-(4,5-dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl]methanesulfonamide and its enantiomers: a novel selective α1A receptor agonist.
Meyer et al.
J.Med.Chem., 1996;39:4116 -
A-61603, a potent α1-adrenergic receptor agonist, selective for the α1A receptor subtype.
Knepper et al.
J.Pharmacol.Exp.Ther., 1995;274:97
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Citations for A 61603 hydrobromide
The citations listed below are publications that use Tocris products. Selected citations for A 61603 hydrobromide include:
12 Citations: Showing 1 - 10
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An Alpha-1A Adrenergic Receptor Agonist Prevents Acute dox. Cardiomyopathy in Male Mice.
Authors: Montgomery
Plos One 2017;12:e0168409
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Divergent regulation of ER and kiss genes by 17�-OE in hypothalamic ARC versus AVPV models.
Authors: Treen Et al.
Mol.Endocrinol. 2016;30:217
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A Myocardial Slice Culture Model Reveals Alpha-1A-Adrenergic Receptor Signaling in the Human Heart.
Authors: Thomas Et al.
JACC Basic Transl Sci 2016;1:155
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The α-1A Adrenergic Receptor in the Rabbit Heart.
Authors: Thomas Et al.
Nephrol Dial Transplant 2016;11:e0155238
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Isoproterenol acts as a biased agonist of the α-1A-adrenoceptor that selectively activates the MAPK/ERK pathway.
Authors: Copik Et al.
PLoS One 2015;10:e0115701
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Renalase in hypertension and kidney disease.
Authors: Desir and Peixoto
Circ Res 2014;29:42604
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p90 ribosomal S6 kinases play a significant role in early gene regulation in the cardiomyocyte response to G(q)-protein-coupled receptor stimuli, endothelin-1 and α(1)-adrenergic receptor agonists.
Authors: Amirak Et al.
Biochem J 2013;450:351
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A molecular MRI probe to detect treatment of cardiac apoptosis in vivo.
Authors: Dash Et al.
Magn Reson Med 2011;66:1152
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Functional alpha-1B adrenergic receptors on human epicardial coronary artery endothelial cells.
Authors: Jensen Et al.
Naunyn Schmiedebergs Arch Pharmacol 2010;382:475
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The α-1D Is the predominant α-1-adrenergic receptor subtype in human epicardial coronary arteries.
Authors: Jensen Et al.
PLoS One 2009;54:1137
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Interaction of α1-adrenoceptor subtypes with different G proteins induces opposite effects on cardiac L-type Ca2+ channel.
Authors: O-Uchi Et al.
PLoS One 2008;102:1378
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Knockout of the alpha 1A/C-adrenergic receptor subtype: the alpha 1A/C is expressed in resistance arteries and is required to maintain arterial blood pressure.
Authors: Rokosh and Simpson
Proc Natl Acad Sci U S A 2002;99:9474
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A61603 was used to treat H9C2 for 24hours, works well as intended.
