A 939572
Chemical Name: 4-(2-Chlorophenoxy)-N-[3-[(methylamino)carbonyl]phenyl]-1-piperidinecarboxamide
Purity: ≥99%
Biological Activity
A 939572 is a potent stearoyl-CoA desaturase 1 (SCD1) inhibitor (IC50 = 0.4 nM). Selective for SCD1 over a range of kinases and hERG channels. Inhibits proliferation of squamous cell carcinoma FaDu cells in vitro. Also induces cell death of undifferentiated human embryonic stem cells (ESCs). Orally bioavailable.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Selective elimination of human pluripotent stem cells by an oleate synthesis inhibitor discovered in a high-throughput screen.
Ben-David et al.
Cell Stem Cell, 2013;12:167 -
Discovery of piperidine-aryl urea-based stearoyl-CoA desaturase 1 inhibitors.
Xin et al.
Bioorg.Med.Chem.Lett., 2008;18:4298
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Citation for A 939572
The citations listed below are publications that use Tocris products. Selected citations for A 939572 include:
1 Citation: Showing 1 - 1
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Low glycaemic diets alter lipid metabolism to influence tumour growth
Authors: Lien Et al.
Nature 2021;599:302
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