AACOCF3
Chemical Name: 1,1,1-Trifluoro-6Z,9Z,12Z,15Z-heneicosateraen-2-one
Biological Activity
AACOCF3 is a inhibitor of cytosolic (85 kDa) phospholipase A2. Also inhibits fatty acid amide hydrolase (FAAH, anandamide amidase) in vitro.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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A novel and essential role for FcgammaRIIa in cancer cell-induced platelet activation.
Mitrugno A, Williams D, Kerrigan S, Moran N
Blood, 2013;123(2):249-60. -
Selective activation of microglia facilitates synaptic strength.
Clark A, Gruber-Schoffnegger D, Drdla-Schutting R, Gerhold K, Malcangio M, Sandkuhler J
J Neurosci, 2015;35(11):4552-70. -
Inhibitors of arachidonoyl ethanolamide hydrolysis.
Koutek et al.
J.Biol.Chem., 1994;269:22937 -
Arachidonyl trifluoromethyl ketone, a potent inhibitor of 85-kDa phospholipase A2, blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets.
Riendeau et al.
J.Biol.Chem., 1994;269:15619 -
Inhibition of calcium-independent phospholipase A2 prevents inflammatory mediator production in pulmonary microvascular endothelium.
Rastogi and McHowat
Respir.Physiol.Neurobiol., 2009;165:167
Product Datasheets
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Citations for AACOCF3
The citations listed below are publications that use Tocris products. Selected citations for AACOCF3 include:
5 Citations: Showing 1 - 5
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Peroxiredoxin 6 mediates Gαi protein-coupled receptor inactivation by cJun kinase.
Authors: Schattauer Et al.
Nat Commun 2017;8:743
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The prostaglandin E2-EP3 receptor axis regulates Anaplasma phagocytophilum-mediated NLRC4 inflammasome activation.
Authors: Wang Et al.
PLoS Pathog. 2016;12:e1005803
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Selective activation of microglia facilitates synaptic strength.
Authors: Clark Et al.
Int J Obes (Lond) 2015;35:4552
-
A novel and essential role for FcγRIIa in cancer cell-induced platelet activation.
Authors: Mitrugno Et al.
Blood 2014;123:249
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Hydrogen sulphide pathway contributes to the enhanced human platelet aggregation in hyperhomocysteinemia.
Authors: Bianca Et al.
Proc Natl Acad Sci U S A 2013;110:15812
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