Home / Calcitonin and Related Receptor Antagonists / AC 187

AC 187

Catalog #: 3419
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3419/500U
AC 187
1 Image
Description: Potent and selective amylin antagonist

Purity: ≥95%

Product Details
Citations (3)
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Biological Activity

AC 187 is an orally active, potent amylin receptor antagonist (IC50 = 0.48 nM) that displays 38-fold and 400-fold selectivity over calcitonin and CGRP receptors respectively. Blocks amyloid β-induced neurotoxicity by attenuating the activation of initiator and effector caspases in vitro. Increases glucagon secretion, accelerates gastric emptying, alters plasma glucose levels and increases food intake in vivo.

Technical Data

M.Wt:
2890.25
Formula:
C127H205N37O40
Sequence:
VLGKLSQELHKLQTYPRTNTGSNTY

(Modifications: Val-1 = N-terminal Ac, Tyr-25 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in water
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
151804-77-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Antagonist of the amylin receptor blocks β-amyloid toxicity in rat cholinergic basal forebrain neurons.
    Jhamandas and MacTavish
    J.Neurosci., 2004;24:5579
  2. Role of endogenous amylin in glucagon secretion and gastric emptying in rats demonstrated with the selective antagonist, AC187.
    Gedulin et al.
    Regul.Pept., 2006;137:121
  3. Amylin receptor blockade stimulates food intake in rats.
    Reidelberger et al.
    Am.J.Physiol.Inter.Comp.Physiol., 2004;287:R568

Product Datasheets

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Citations for AC 187

The citations listed below are publications that use Tocris products. Selected citations for AC 187 include:

3 Citations: Showing 1 - 3

  1. Contraction of human brain vascular pericytes in response to islet amyloid polypeptide is reversed by pramlintide.
    Authors: Nuñez-Diaz Et al.
    Mol Brain  2023;16:25
  2. The satiating hormone amylin enhances neurogenesis in the area postrema of adult rats.
    Authors: Liberini Et al.
    Mol Metab  2016;5:834
  3. Antipsychotic-like actions of the satiety peptide, amylin, in ventral striatal regions marked by overlapping calcitonin receptor and RAMP-1 gene expression.
    Authors: Baisley Et al.
    J Neurosci  2014;34:4318

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