AC 265347
Chemical Name: α-(2,4-Dimethylphenyl)-α-methyl-2-benzothiazolemethanol
Purity: ≥99%
Biological Activity
AC 265347 is a CaSR biased allosteric modulator (pEC50 = 7.8-8.1). Calcimimetic. Displays ability to bias signalling towards the accumulation of pERK1/2 and IP1. Reduces parathyroid hormone (PTH) levels in rat serum without inducing the release of calcitonin. Exhibits no significant activation of human GABAB or type I PTH receptors. Orally active.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics.
Cook et al.
Br.J.Pharmacol., 2015;172:185 -
Characterization of highly efficacious allosteric agonists of the human calcium-sensing receptor.
Ma et al.
J.Pharmacol.Exp.Ther., 2011;337:275 -
Towards a structural understanding of allosteric drugs at the human calcium-sensing receptor.
Leach et al.
Cell.Res., 2016;26:574
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