Ac2-26

Biological Activity

Ac2-26 is an annexin/lipocortin 1-mimetic peptide; inhibits leukocyte extravasation. Ac2-26 reduces neutrophil adhesion and emigration, promotes detachment of neutrophils from activated mesenteric endothelium and accelerates epithelial wound repair after induced colonic injury in mice in vivo. Anti-inflammatory. Ac2-26 inhibits the proliferation of human larynx epidermoid carcinoma Hep-2 cells in vitro. Ac2-26 decreases proliferation and increases mobility of cervical cancer cells.

Negative control also available.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair.
   Leoni, Giovanna, Neumann, Philipp-, Kamaly, Nazila, Quiros, Miguel, Nishio, Hikaru, Jones, Hefin R, Sumagin, Ronen, Hilgarth, Roland S, Alam, Ashfaqul, Fredman, Gabriell, Argyris, Ioannis, Rijcken, Emile, Kusters, Dennis, Reutelingsperger, Chris, Perretti, Mauro, Parkos, Charles, Farokhzad, Omid C, Neish, Andrew S, Nusrat, Asma
   J Clin Invest, 2015;125(3):1215-27.
2. The role and effects of glucocorticoid-induced leucine zipper in the context of inflammation resolution.
   Vago J, Tavares L, Garcia C, Lima K, Perucci L, Vieira E, Nogueira C, Soriani F, Martins J, Silva P, Gomes K, Pinho V, Bruscoli S, Riccardi C, Beaulieu E, Morand E, Teixeira M, Sousa L
   J Immunol, 2015;194(10):4940-50.
3. Hyperosmolar stress induces neutrophil extracellular trap formation: implications for dry eye disease.
   Tibrewal S, Ivanir Y, Sarkar J, Nayeb-Hashemi N, Bouchard C, Kim E, Jain S
   Invest Ophthalmol Vis Sci, 2014;55(12):7961-9.
4. Role of intracellular and extracellular annexin A1 in migration and invasion of human pancreatic carcinoma cells.
   Belvedere, Raffaell, Bizzarro, Valentin, Popolo, Ada, Dal Piaz, Fabrizio, Vasaturo, Michele, Picardi, Paola, Parente, Luca, Petrella, Antonell
   BMC Cancer, 2014;14(0):961.
5. Promoting detachment of neutrophils adherent to murine postcapillary venules to control inflammation: effect of lipocortin 1.
   Lim et al.
   Proc.Natl.Acad.Sci.U.S.A., 1998;95:14535
6. Lipocortin-1 fragments inhibit neutrophil accumulation and neutrophil-dependent edema in the mouse. A qualitative comparison with an anti-CD11b monoclonal antibody.
   Perretti et al.
   J.Immunol., 1993;151:4306
7. Annexin 1: an endogenous anti-inflammatory protein.
   Perretti and Gavins
   News Physiol.Sci., 2003;18:60

Product Datasheets