Acridine Orange hydrochloride
Chemical Name: N,N,N',N'-Tetramethyl-3,6-acridinediamine hydrochloride
Purity: ≥98%
Biological Activity
Acridine Orange hydrochloride is a cell and organelle membrane permeable nucleic acid binding dye. Emits green fluorescence when bound to double-stranded DNA and red fluorescence when bound to RNA or single-stranded DNA. Used in cell cycle and apoptosis studies and as a lysosomal dye.This product is supplied as a hydrochloride salt, the stoichiometry of which is batch dependent. Please refer to the Certificate of Analysis to obtain the batch specific Net Product Content.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Chemoresistance to concanamycin A1 in human oral squamous cell carcinoma is attenuated by an HDAC inhibitor partly via suppression of Bcl-2 expression.
Kiyoshima et al.
PLoS ONE, 2013;8:80998 -
Analysis of single and double stranded nucleic acids on polyacrylamide and agarose gels by using glyoxal and acridine orange.
McMaster et al.
Proc.Natl.Acad.Sci.USA, 1977;74:4835 -
Rapid communication: oxidative stress induces apoptosis in embryonic cortical neurons.
Ratan et al.
J.Neurobiol., 2008;62:376
Product Datasheets
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Citation for Acridine Orange hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Acridine Orange hydrochloride include:
1 Citation: Showing 1 - 1
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Imatinib disturbs lysosomal function and morphology and impairs the activity of mTORC1 in human hepatocyte cell lines.
Authors: Stephan Et al.
Food Chem Toxicol 2022;162:112869
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