Home / Orexin Receptor Antagonists / ACT 462206

ACT 462206

Catalog #: 5319
1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5319/10
5319/50
ACT 462206 | CAS No. 1361321-96-1 | Orexin Receptor Antagonists
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Description: Potent, dual orexin receptor antagonist

Chemical Name: (2S)-N-(3,5-Dimethylphenyl)-1-[(4-methoxyphenyl)sulfonyl]-2-pyrrolidinecarboxamide

Purity: ≥99%

Product Details
Citations (1)
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Biological Activity

ACT 462206 is a potent, dual orexin receptor antagonist (IC50 values are 11 and 60 nM for OX2 and OX1 receptors respectively). Exhibits anxiolytic-like properties in vivo. Brain penetrant.

Technical Data

M.Wt:
388.48
Formula:
C20H24N2O4S
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
1361321-96-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for ACT 462206

The citations listed below are publications that use Tocris products. Selected citations for ACT 462206 include:

1 Citation: Showing 1 - 1

  1. Hypothalamic kinin B1 receptor mediates orexin system hyperactivity in neurogenic hypertension.
    Authors: Abdel A Et al.
    Sci Rep  2021;11:21050

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