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α-Amanitin

Catalog #: 4025
4 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4025/1
α-Amanitin | CAS No. 23109-05-9 | RNA/DNA Polymerase Inhibitors
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Description: Inhibitor of RNA polymerase II

Chemical Name: cyclo[L-Asparaginyl-4-hydroxy-L-proly-(R-4,5-dihydroxy-L-isoleucyl-6-hydroxy-2-mercapto-L-tryptophylglycyl-L-isoleucylglycyl-L-cysteinyl]cyclic (4→8)-sulfide (R)-S-oxide

Purity: ≥95%

Product Details
Citations (4)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

α-Amanitin is an inhibitor of RNA polymerase II. Inhibits transcription in eukaryotic cells. Binds and blocks the largest subunits of RNA polymerase II, preventing new ribonucleotides from incorporating into the nascent RNA chain. Potent amatoxin.

Technical Data

M.Wt:
918.97
Formula:
C39H54N10O14S
Solubility:
Soluble to 5 mM in water
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
23109-05-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. The transcriptional inhibitors, actinomycin D and α-amanitin, activate the HIV-1 promoter and favor phosphorylation of the RNA polymerase II C-terminal domain.
    Casse et al.
    J.Biol.Chem., 1999;274:16097
  2. Close association of RNA polymerase II and many transcription factors with Pol III genes.
    Raha et al.
    Proc.Natl.Acad.Sci., 2010;107:3639

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Citations for α-Amanitin

The citations listed below are publications that use Tocris products. Selected citations for α-Amanitin include:

4 Citations: Showing 1 - 4

  1. BRD2 compartmentalizes the accessible genome.
    Authors: Rafael Et al.
    Nat Genet  2022;54:481-491
  2. Loss of centromeric RNA activates the spindle assembly checkpoint in mammalian female meiosis I.
    Authors: Feng Et al.
    J Cell Biol  2021;220
  3. HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains.
    Authors: Philip R Et al.
    Nat Commun  2020;11:3505
  4. Remodeling of Interstrand Crosslink Proximal Replisomes Is Dependent on ATR, FANCM, and FANCD2.
    Authors: Jing Et al.
    Cell Rep  2019;27:1794-1808.e5

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