AMT hydrochloride
Chemical Name: 2-Amino-5,6-dihydro-6-methyl-4H-1,3-thiazine hydrochloride
Biological Activity
AMT hydrochloride is a potent, selective and reversible inhibitor of iNOS (IC50 = 3.6 nM; approximately 30 and 40 times selective over nNOS and eNOS respectively).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
Nitric oxide signaling in stretch-induced apoptosis of neonatal rat cardiomyocytes.
Liao et al.
FASEB J., 2006;20:E1196 -
Novel potent and selective inhibitors of inducible nitric oxide synthase.
Nakane et al.
Mol.Pharmacol., 1995;47:831 -
Inhibition of sarcoplasmic reticular function by chronic interleukin-6 exposure via iNOS in adult ventricular myocytes.
Yu et al.
J.Physiol., 2005;566:327
Product Datasheets
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Citations for AMT hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for AMT hydrochloride include:
5 Citations: Showing 1 - 5
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Ginsenosides from Korean Red Ginseng ameliorate lung inflammatory responses: inhibition of the MAPKs/NF-κB/c-Fos pathways.
Authors: Lee Et al.
J Ginseng Res 2018;42:476
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Role of inducible nitric oxide synthase in endothelium-independent relaxation to RLX in rat aorta.
Authors: Wong Et al.
Br J Pharmacol 2017;174:718
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Inhibition of Lung Inflammation by Acanthopanax divaricatus var. Albeofructus and Its Constituents.
Authors: Lee Et al.
PLoS One 2016;24:67
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Involvement of nitric oxide in the modulation of dural arterial blood flow in the rat.
Authors: Messlinger Et al.
Br J Pharmacol 2000;129:1397
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Pharmacological and immunohistochemical evidence for a functional nitric oxide synthase system in rat peritoneal eosinophils.
Authors: Zanardo Et al.
Proc Natl Acad Sci U S A 1997;94:14111
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