(+)-Anabasine hydrochloride
Chemical Name: (S)-(+)-3-(2-Piperidinyl)pyridine hydrochloride
Purity: ≥99%
Biological Activity
(+)-Anabasine hydrochloride is a high affinity neuronal nicotinic ACh receptor partial agonist (Ki values are 0.058, 0.26 and 7.2 μM for rat α7, rat α4β2 and fish skeletal muscle nAChRs respectively). Also stimulates Ca2+-dependent catecholamine release from rat adrenomedullary cells in vitro.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Anabaseine is a potent agonist on muscle and neuronal alpha-bungarotoxin-sensitive nicotinic receptors.
Kem et al.
J.Pharmacol.Exp.Ther., 1997;283:979 -
Neuronal nicotinic receptor β2 and β4 subunits confer large differences in agonist binding affinity.
Parker et al.
Mol.Pharmacol., 1998;54:1132 -
Desensitization of nicotinic agonist-induced [3H]γ-aminobutyric acid release from mouse brain synaptosomes is produced by subactivating concentrations of agonists.
Lu et al.
J.Pharmacol.Exp.Ther., 1999;291:1127 -
Effect of anabasine on catecholamine secreation from the perfused rat adrenal medulla.
Hong et al.
J.Cardiol., 2007;50:351
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