Anastrozole
Chemical Name: α1,α1,α3,α3-Tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-benzenediacetonitrile
Purity: ≥99%
Biological Activity
Anastrozole is a potent and highly selective aromatase (CYP19) inhibitor (IC50 = 15 nM) that has no discernible effect on adrenocorticoid hormone synthesis. Reduces plasma estrogen levels and exhibits antitumor activity in vivo. Orally active.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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The preclinical pharmacology of "Arimidex" (anastrozole; ZD1033)-a potent, selective aromatase inhibitor.
Dukes et al.
J.Steroid Biochem.Mol.Biol., 1996;58:439 -
Anastrozole: a new selective nonsteroidal aromatase inhibitor.
Goss and Tye
Oncology, 1997;11:1697 -
Anastrozole (ArimidexTM) - an aromatase inhibitor for the adjuvant setting?
Buzda
Br.J.Cancer, 2001;85:6
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