Anti- Adalimumab (Anti-Idiotype) Antibody Summary
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
![Detection of Adalimumab antibody by Western Blot. Detection of Adalimumab antibody by Western Blot.](https://resources.rndsystems.com/images/datasheets/antibody/Adalimumab_MAB9546_Western_Blot_21372.jpg)
Detection of Adalimumab by Western Blot. Western blot shows Trastuzumab (negative control), Adalimumab, Ibritumomab (negative control), and Tostiumomab (negative control) biosimilars. PVDF membrane was probed with 2 µg/mL of Anti- Adalimumab (Anti-Idiotype) Monoclonal Antibody (Catalog # MAB9546) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (HAF018). A specific band was detected for Adalimumab at approximately 240 kDa (as indicated). This experiment was conducted under non-reducing conditions and using Immunoblot Buffer Group 1.
![Specificity of Anti-Adalimumab (Anti-Idiotype) Antibody in Antibody in ELISA Capture Assay. Specificity of Anti-Adalimumab (Anti-Idiotype) Antibody in Antibody in ELISA Capture Assay.](https://resources.rndsystems.com/images/datasheets/antibody/Adalimumab_MAB9546_ELISA_21506.jpg)
Specificity of Anti-Adalimumab (Anti-Idiotype) Antibody in ELISA Capture Assay. Biotinylated biosimilars were serially diluted and incubated with Anti-Adalimumab (Anti-Idiotype) Antibody (Catalog # MAB9546, green line) coated at 1 μg/mL on a 96-well polystyrene plate. No cross-reactivity with Trastuzumab (black line) or Gemtuzumab (orange line) was observed.
![Specificity of Anti-Adalimumab (Anti-Idiotype) Antibody in Direct Antibody in ELISA. Specificity of Anti-Adalimumab (Anti-Idiotype) Antibody in Direct Antibody in ELISA.](https://resources.rndsystems.com/images/datasheets/antibody/Adalimumab_MAB9546_ELISA_21611.jpg)
Specificity of Anti-Adalimumab (Anti-Idiotype) Antibody in Direct ELISA. A panel of biosimilars was coated at 1 μg/mL in 96-well polystyrene plates. Anti-Adalimumab (Anti-Idiotype) Antibody (Catalog # MAB9546, 333 ng/mL) detected Adalimumab. No cross-reactivity with Cetuximab, Rituximab, Trastuzumab, Brentuximab, Gemtuzumab, Ibritumomab, Tositumomab, Solanezumab, Teprotumumab, and Aducanumab was observed.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Adalimumab
The anti-Adalimumab antibody is an anti-Idiotype antibody raised against and selected for the antigenic determinants of the variable region of Adalimumab. The antibody has been tested against a broad range of other biosimilars to ensure specificity. This highly specialized anti-idiotypic antibody can be used in a variety of pharmacokinetic (PK) assay formats.
Product Datasheets
FAQs
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What is an anti-idiotype antibody?
An anti-idiotype antibody is specific for the unique variable (antigen binding) region of another antibody. We have anti-idiotype antibodies to commecially available therapeutic antibodies or biosimilars.
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