Aphidicolin
Chemical Name: (3R,4R,4aR,6aS,8R,9R,11aS,11bS)-Tetradecahydro-3,9-dihydroxy-4,11b-dimethyl-8,11a-methano-11aH-cyclohepta[a]naphthalene-4,9-dimethanol
Purity: ≥98%
Biological Activity
Aphidicolin is a DNA polymerase α, δ and ε inhibitor. Exhibits selectivity over DNA polymerase β and γ. Antimitotic, antibiotic and antiviral.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Control of DNA replication and cell proliferation in eukaryotes by aphidicolin.
Spadari et al.
Toxicol.Pathol., 1984;12:143 -
Antiviral effects of aphidicolin, a new antibiotic produced by Cephalosporium aphidicola.
Bucknall et al.
Antimicrob.Agents Chemother., 1973;4:294 -
DNA polymerases α, δ, and ε: three distinct enzymes from HeLa cells.
Syväoja et al.
Proc.Natl.Acad.Sci.U.S.A., 1990;87:6664
Product Datasheets
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Citation for Aphidicolin
The citations listed below are publications that use Tocris products. Selected citations for Aphidicolin include:
1 Citation: Showing 1 - 1
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Genetic and Mechanical Regulation of Intestinal Smooth Muscle Development.
Authors: Clifford J Et al.
Cell 2019;179:90-105.e21
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