Arctigenin
Chemical Name: (3R,4R)-4-[(3,4-Dimethoxyphenyl)methyl]dihydro-3-[(4-hydroxy-3-methoxyphenyl)methyl]-2(3H)-furanone
Purity: ≥98%
Biological Activity
Arctigenin is an antioxidant, anti-inflammatory, antiproliferative and antiviral agent. Inhibits LPS-induced iNOS expression via inhibition of IκBα phosphorylation and p65 nuclear translocation (IC50 = 10 nM). Inhibits HIV-1 replication in vitro. Also potently inhibits MKK1 (MEK1) (IC50 = 0.5 nM) and provides neuroprotection by binding to kainate receptors.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Potent inhibition of lipopolysaccharide-inducible nitric oxide synthase expression by dibenzylbutyrolactone lignans through inhibition of I-κBα phosphorylation and of p65 nuclear translocation.
Cho et al.
Int.Immunopharmacol., 2002;2:105 -
Arctigenin protects cultured cortical neurons from glutamate-induced neurodegeneration by binding to kainate receptor.
Jang et al.
J.Neurosci.Res., 2002;68:233 -
Differential in vitro anti-HIV activity of natural lignans.
Schroder et al.
Z.Naturforsch.C., 1990;45:1215 -
Arctigenin, a potent inhibitor of MKK1, inhibits lipopolysaccharide (LPS)-inducible nitric oxide synthase expression through inhibition of I-κBα phosphorylation and of p65 nuclear translocation.
Cho et al.
Exp.Biol.Abstr., 2003;:152.2
Product Datasheets
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Citations for Arctigenin
The citations listed below are publications that use Tocris products. Selected citations for Arctigenin include:
2 Citations: Showing 1 - 2
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Longitudinal tracking of subpopulation dynamics and molecular changes during LNCaP cell castration and identification of inhibitors that could target the PSA-/lo castration-resistant cells.
Authors: Rycaj Et al.
Oncotarget 2016;7:14220
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(-) Arctigenin and (+) pinoresinol are antagonists of the human thyroid hormone receptor β.
Authors: Ogungbe Et al.
J Chem Inf Model 2014;54:3051
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