ARL 17477 dihydrochloride

Catalog #: 3319
1 Citation Datasheet / COA / SDS

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ARL 17477 dihydrochloride | CAS No. 866914-87-6 | nNOS Inhibitors

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Description: Selective nNOS inhibitor

Chemical Name: N-[4-[2-[[(3-Chlorophenyl)methyl]amino]ethyl]phenyl]-2-thiophenecarboxamide dihydrochloride

Purity: ≥99%

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Product Details

Citations (1)

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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

ARL 17477 dihydrochloride is a selective neuronal nitrogen oxide synthase (nNOS) inhibitor (IC₅₀ values are 1 and 17 μM for nNOS and endothelial NOS respectively). Reduces ischemic cell damage after middle cerebral artery (MCA) occlusion in rats. Displays a synergistic neuroprotective effect when combined with either an NMDA or AMPA receptor antagonist.

Technical Data

M.Wt:

442.83

Formula:

C₂₀H₂₀ClN₃S.2HCl

Solubility:

Soluble to 50 mM in water and to 100 mM in DMSO

Purity:

≥99%

Storage:

Desiccate at RT

CAS No:

866914-87-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:

Sold with the permission of AstraZeneca UK Ltd.

Background References

Synergistic neuroprotective effects by combining an NMDA or AMPA receptor antagonist with nitric oxide synthase inhibitors in global cerebral ischaemia.
Hicks et al.
Eur.J.Pharmacol., 1999;381:113
ARL 17477, a selective nitric oxide synthase inhibitor, with neuroprotective effects in animal models of global and focal cerebral ischaemia.
O'Neill et al.
Brain Res., 2000;871:234

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Citation for ARL 17477 dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for ARL 17477 dihydrochloride include:

1 Citation: Showing 1 - 1

Calcium Ionophore, Calcimycin, Kills Leishmania Promastigotes by Activating Parasite Nitric Oxide Synthase.
Authors: Grekov Et al.
Biomed Res Int 2017;2017:1309485

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